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Resveratrol, a Natural Antioxidant, Has a Protective Effect on Liver Injury Induced by Inorganic Arsenic Exposure
- Source :
- BioMed Research International, Vol 2014 (2014), BioMed Research International
- Publication Year :
- 2014
- Publisher :
- Hindawi Limited, 2014.
-
Abstract
- Resveratrol (Rev) can ameliorate cytotoxic chemotherapy-induced toxicity and oxidative stress. Arsenic trioxide (As2O3) is a known cytotoxic environmental toxicant and a potent chemotherapeutic agent. However, the mechanisms by which resveratrol protects the liver against the cytotoxic effects of As2O3are not known. Therefore, in the present study we investigated the mechanisms involved in the action of resveratrol using a cat model in which hepatotoxicity was induced by means of As2O3treatment. We found that pretreatment with resveratrol, administered using a clinically comparable dose regimen, reversed changes in As2O3-induced morphological and liver parameters and resulted in a significant improvement in hepatic function. Resveratrol treatment also improved the activities of antioxidant enzymes and attenuated As2O3-induced increases in reactive oxygen species and malondialdehyde production. In addition, resveratrol attenuated the As2O3-induced reduction in the ratio of reduced glutathione to oxidized glutathione and the retention of arsenic in liver tissue. These findings provide a better understanding of the mechanisms whereby resveratrol modulates As2O3-induced changes in liver function and tissue morphology. They also provide a stronger rationale for the clinical utilization of resveratrol for the reduction of As2O3-induced hepatotoxicity.
- Subjects :
- Antioxidant
Article Subject
medicine.medical_treatment
lcsh:Medicine
Resveratrol
Pharmacology
medicine.disease_cause
Antioxidants
Arsenicals
General Biochemistry, Genetics and Molecular Biology
Arsenic
chemistry.chemical_compound
Arsenic Trioxide
Malondialdehyde
Stilbenes
medicine
Animals
Arsenic trioxide
skin and connective tissue diseases
Liver injury
General Immunology and Microbiology
business.industry
Liver Diseases
lcsh:R
food and beverages
Oxides
Environmental Exposure
General Medicine
Glutathione
Environmental exposure
medicine.disease
Oxidative Stress
Liver
chemistry
Cats
Liver function
Reactive Oxygen Species
business
Oxidative stress
Research Article
Subjects
Details
- ISSN :
- 23146141 and 23146133
- Volume :
- 2014
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....f62d65529d4501ab18f40137db822d73