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Clinical Outcomes of Patients with Advanced Cancer and Pre-Existing Autoimmune Diseases Treated with Anti-Programmed Death-1 Immunotherapy: A Real-World Transverse Study
- Publication Year :
- 2019
-
Abstract
- BACKGROUND. Patients with a history of autoimmune diseases (AIDs) have not usually been included in clinical trials with immune checkpoint inhibitors. MATERIALS AND METHODS. Consecutive patients with advanced cancer, treated with anti‐programmed death‐1 (PD‐1) agents, were evaluated according to the presence of pre‐existing AIDs. The incidence of immune‐related adverse events (irAEs) and clinical outcomes were compared among subgroups. RESULTS. A total of 751 patients were enrolled; median age was 69 years. Primary tumors were as follows: non‐small cell lung cancer, 492 (65.5%); melanoma, 159 (21.2%); kidney cancer, 94 (12.5%); and others, 6 (0.8%). Male/female ratio was 499/252. Eighty‐five patients (11.3%) had pre‐existing AIDs, further differentiated in clinically active (17.6%) and inactive (82.4%). Among patients with pre‐existing AIDs, incidence of irAEs of any grade was significantly higher when compared with patients without AIDs (65.9% vs. 39.9%). At multivariate analysis, both inactive (p = .0005) and active pre‐existing AIDs (p = .0162), female sex (p = .0004), and Eastern Cooperative Oncology Group Performance Status
- Subjects :
- Adult
Male
0301 basic medicine
Cancer Research
medicine.medical_specialty
Drug-Related Side Effects and Adverse Reactions
medicine.medical_treatment
Programmed Cell Death 1 Receptor
Severity of Illness Index
Autoimmune Diseases
Young Adult
03 medical and health sciences
Immune checkpoint inhibitors
Antineoplastic Agents, Immunological
0302 clinical medicine
Acquired immunodeficiency syndrome (AIDS)
Neoplasms
Internal medicine
Autoimmune disease
medicine
Humans
Anti-programmed death-1
Immunotherapy
Performance status
Sex
Oncology
Adverse effect
Aged
Retrospective Studies
Aged, 80 and over
business.industry
Incidence
Incidence (epidemiology)
Middle Aged
medicine.disease
Immuno‐Oncology
Progression-Free Survival
Clinical trial
030104 developmental biology
030220 oncology & carcinogenesis
Female
business
Kidney cancer
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....f637b071e8addffb1e6e970c8b3d33bb