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GLP-1 RA Treatment and Dosing Patterns Among Type 2 Diabetes Patients in Six Countries: A Retrospective Analysis of Pharmacy Claims Data
- Source :
- Diabetes Therapy
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Introduction The glucagon-like peptide-1 receptor agonist (GLP-1 RA) class is evolving and expanding. This retrospective database study evaluated recent real-world treatment and dosing patterns of patients with type 2 diabetes (T2D) initiating GLP-1 RAs in Belgium (BE), France (FR), Germany (DE), Italy (IT), the Netherlands (NL), and Canada (CA). Methods Adult T2D patients initiating GLP-1 RA therapy (dulaglutide [DULA], exenatide twice daily [exBID], exenatide once weekly [exQW], liraglutide [LIRA], or lixisenatide [LIXI]) from 2015 to 2016 were identified using the IQVIA (IQVIA, Durham, NC, and Danbury, CT, USA) Real-World Data Adjudicated Pharmacy Claims. The therapy initiation date was termed the ‘index date.’ Eligible patients had ≥ 180 days pre-index and ≥ 360 days post-index. Persistence (until discontinuation or switch) was evaluated over the variable follow-up using Kaplan–Meier (KM) survival analysis. Average daily dose (ADD) was calculated until discontinuation or switch. Results A total of 34,649 DULA, 3616 exBID, 11,138 exQW, 48,317 LIRA, and 2,204 LIXI patients were included in the analysis (34.9–63.2% female; median age range 53–62 years; median follow-up 16–30 months). Proportion persistent at 1-year post-index was 36.8–67.2% for DULA, 5.9–44.4% for exBID, 24.7–44.2% for exQW, 22.2–57.5% for LIRA, and 15.5–40.0% for LIXI. Median time persistent (days) was 245–381 for DULA, 62–243 for exBID, 121–319 for exQW, 103–507 for LIRA, and 99–203 for LIXI. Mean ADD was 13.21–20.43 µg for exBID, 1.44–1.68 mg for LIRA, and 19.88–20.54 µg for LIXI. Mean average weekly dose (AWD) ranged from 2.03 to 2.14 mg for exQW. Mean AWD for DULA was 1.25 mg in Canada and ranged from 1.43 to 1.53 mg in the other countries. Conclusion Across six countries, persistence was highest among DULA patients and generally lowest among exBID patients. ADD/AWD for all GLP-1 RAs was in line with the recommended label. Longer-term data would be useful to obtain a better understanding of GLP-1 RA treatment patterns over time. Funding Eli Lilly and Company, Indianapolis, IN, USA. Electronic Supplementary Material The online version of this article (10.1007/s13300-019-0615-5) contains supplementary material, which is available to authorized users.
- Subjects :
- Agonist
endocrine system
medicine.medical_specialty
medicine.drug_class
Endocrinology, Diabetes and Metabolism
Lixisenatide
030209 endocrinology & metabolism
Pharmacy
Type 2 diabetes
030204 cardiovascular system & hematology
Persistence
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Dosing
Dulaglutide
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs)
Exenatide QW
Original Research
Liraglutide
business.industry
Exenatide BID
medicine.disease
chemistry
business
medicine.drug
Subjects
Details
- ISSN :
- 18696961 and 18696953
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Diabetes Therapy
- Accession number :
- edsair.doi.dedup.....f63cc13c454ffebc6760930fbafa388d
- Full Text :
- https://doi.org/10.1007/s13300-019-0615-5