Back to Search
Start Over
The prognostic value of serum albumin levels and respiratory rate for community-acquired pneumonia: A prospective, multi-center study
- Source :
- PLoS ONE, Vol 16, Iss 3, p e0248002 (2021), PLoS ONE
- Publication Year :
- 2021
- Publisher :
- Public Library of Science (PLoS), 2021.
-
Abstract
- Community-acquired pneumonia (CAP) is a respiratory disease frequently requiring hospital admission, and a significant cause of death worldwide. This study aimed to investigate the prognostic value of clinical indicators. A prospective, multi-center study was conducted (January 2017–December 2018) where patient demographic and clinical data were recorded (N = 366). The 30-day mortality rate was 5.46%. Cox Regression analyses showed that serum albumin (ALB) and respiratory rate (RR) were independent prognostic variables for 30-day survival in patients with CAP. Albumin negatively correlated with the Pneumonia Severity Index (PSI) and CURB-65 scores using Pearson and Spearman tests. Survival curves showed that a RR >24 breaths/min or ALB ≤30 g/L were associated with a significantly higher risk of mortality. The area-under-the-curve (AUC) for predicting 30-day mortality in patients with CAP was 0.762, 0.763, 0.790, and 0.784 for ALB, RR, PSI, and CURB-65, respectively. The AUC for the prediction of 30-day mortality using ALB combined with PSI, CURB-65 scores, and RR was 0.822 (95% CI 0.731–0.912), 0.847 (95% CI 0.755–0.938), and 0.847 (95% CI 0.738–0.955), respectively. Albumin and RR were found to be reliable prognostic factors for CAP. This combination showed equal predictive value when compared to adding ALB assessment to PSI and CURB-65 scores, which could improve their prognostic accuracy.
- Subjects :
- Male
Pulmonology
Physiology
Epidemiology
Pneumonia severity index
Severity of Illness Index
Biochemistry
Gastroenterology
Mathematical and Statistical Techniques
0302 clinical medicine
Community-acquired pneumonia
Medicine and Health Sciences
Risk of mortality
Urea
Prospective Studies
030212 general & internal medicine
Multidisciplinary
biology
Organic Compounds
Respiration
Mortality rate
Statistics
Respiratory disease
Middle Aged
Prognosis
C-Reactive Proteins
Community-Acquired Infections
Chemistry
Area Under Curve
Physical Sciences
Regression Analysis
Medicine
Female
Research Article
medicine.medical_specialty
Prognostic variable
Science
Serum albumin
Serum Albumin, Human
Research and Analysis Methods
03 medical and health sciences
Respiratory Rate
Diagnostic Medicine
Albumins
Internal medicine
medicine
Humans
Statistical Methods
Survival analysis
Aged
business.industry
Organic Chemistry
Chemical Compounds
Biology and Life Sciences
Proteins
Pneumonia
medicine.disease
030228 respiratory system
Medical Risk Factors
biology.protein
Physiological Processes
business
Mathematics
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 16
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....f63fd64b149c60c32db1594006afefcd