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A Prospective Cohort Study Showing No Association Between Serum Sclerostin Level and Mortality in Maintenance Hemodialysis Patients
A Prospective Cohort Study Showing No Association Between Serum Sclerostin Level and Mortality in Maintenance Hemodialysis Patients
- Source :
- Kidney & Blood Pressure Research, Vol 43, Iss 3, Pp 1023-1033 (2018)
- Publication Year :
- 2018
- Publisher :
- S. Karger AG, 2018.
-
Abstract
- Background/Aims: Potential relationships between serum sclerostin levels and the levels of bone metabolic markers in maintenance hemodialysis (MHD) patients have yet to be evaluated. This study sought to determine whether serum sclerostin levels are associated with mortality in MHD patients. Methods: We measured serum sclerostin levels in a Japanese MHD cohort, classified the patients into tertiles according to these levels, and followed their course for a 42-month period. Results: The cohort consisted of 389 MHD patients and there were 75 deaths. Kaplan-Meier analyses showed that the tertile of serum sclerostin was not associated with mortality risk. Cox analyses showed that there were no significant associations between serum sclerostin level and mortality. Conclusion: Serum sclerostin level was not an independent predictor of mortality in MHD patients after adjustment for several confounders. However, whether clinical interventions to modulate serum sclerostin levels in MHD patients would improve their survival remains to be determined.
- Subjects :
- Genetic Markers
Male
Aortic calcification
0301 basic medicine
lcsh:Diseases of the circulatory (Cardiovascular) system
medicine.medical_specialty
Sclerostin
medicine.medical_treatment
030232 urology & nephrology
Kaplan-Meier Estimate
lcsh:RC870-923
Independent predictor
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Asian People
Renal Dialysis
Internal medicine
CKD-MBD
lcsh:Dermatology
medicine
Humans
Prospective Studies
Renal Insufficiency, Chronic
Mortality
Prospective cohort study
Adaptor Proteins, Signal Transducing
Aged
business.industry
Confounding
General Medicine
Maintenance hemodialysis
Middle Aged
lcsh:RL1-803
lcsh:Diseases of the genitourinary system. Urology
030104 developmental biology
chemistry
lcsh:RC666-701
Nephrology
Hemodialysis
Bone Morphogenetic Proteins
Metabolic markers
Cohort
Female
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 14230143 and 14204096
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Kidney and Blood Pressure Research
- Accession number :
- edsair.doi.dedup.....f66dbfd74f5107e3bbb48c50a36d5027
- Full Text :
- https://doi.org/10.1159/000490824