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Improved high-quality colon cleansing with 1L NER1006 versus 2L polyethylene glycol + ascorbate or oral sulfate solution
- Source :
- Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 51(12)
- Publication Year :
- 2019
-
Abstract
- Background & aims Colonoscopy requires bowel cleansing for gut mucosa visualization; high-quality cleansing facilitates lesion detection. NER1006 is a 1L polyethylene glycol (PEG) bowel preparation. This post hoc analysis of two randomized trials investigated cleansing efficacy assessed, as in clinical practice, by site endoscopists. Methods Patients received NER1006, 2L PEG + ascorbate (2LPEG), or oral sulfate solution (OSS) as a 2-day evening/morning regimen (N2D) or NER1006 morning-only dosing (N1D). Treatment-blinded site endoscopists assessed cleansing using the Harefield Cleansing Scale (HCS). Analyses were conducted in a modified full analysis set, including (mFAS; n = 1378) or excluding (mFAS2; n = 1319) imputed failures, and in patients with 100% treatment adherence (mFAS100; n = 1047). Overall cleansing success (HCS grade A/B), overall high-quality cleansing (HCS grade A), and high-quality segments (HCS 3–4) per treatment population were analyzed. Results Overall cleansing success was higher with N2D than 2LPEG (92.7–97.5% vs. 87.9–93.0%), and more patients had overall high-quality cleansing with N2D and N1D than 2LPEG (68.0–72.1% and 64.0–68.4% vs. 50.7–56.0%). Without imputed failures, N2D delivered more overall high-quality cleansing than OSS (74.5–77.3% vs. 67.8–69.8%). More high-quality segments were demonstrated with N2D and N1D versus 2 LPEG (82.5–87.1% and 79.4–84.4% vs. 70.4–76.3%) and with N2D versus OSS (82.7–89.5% vs. 78.1–84.4%). Conclusion When assessed by site endoscopists, NER1006 delivers greater high-quality cleansing than 2LPEG or OSS.
- Subjects :
- Male
medicine.medical_specialty
Colon
medicine.medical_treatment
Population
Colon cleansing
Colonoscopy
Polyethylene glycol
Ascorbic Acid
Gastroenterology
law.invention
Polyethylene Glycols
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Randomized controlled trial
law
Internal medicine
Post-hoc analysis
Outcome Assessment, Health Care
Preoperative Care
medicine
Humans
Dosing
education
education.field_of_study
Hepatology
medicine.diagnostic_test
business.industry
Cathartics
Sulfates
Middle Aged
Quality Improvement
Regimen
chemistry
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
Female
business
Colorectal Neoplasms
Subjects
Details
- ISSN :
- 18783562
- Volume :
- 51
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
- Accession number :
- edsair.doi.dedup.....f69365974417607fbb3325697b396e98