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Maladaptive compensation of right fusiform gyrus in developmental dyslexia: A hub-based white matter network analysis

Authors :
Jingjing Zhao
Franck Ramus
Irene Altarelli
Michel Thiebaut de Schotten
Tianqiang Liu
Université de Paris (UP)
Laboratoire de psychologie du développement et de l'éducation de l'enfant (LaPsyDÉ - UMR 8240)
Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)
Laboratoire de sciences cognitives et psycholinguistique (LSCP)
Département d'Etudes Cognitives - ENS Paris (DEC)
École normale supérieure - Paris (ENS Paris)
Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris)
Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École des hautes études en sciences sociales (EHESS)-Centre National de la Recherche Scientifique (CNRS)
Source :
Cortex, Cortex, Elsevier, 2021, 145, pp.57-66. ⟨10.1016/j.cortex.2021.07.016⟩
Publication Year :
2021
Publisher :
HAL CCSD, 2021.

Abstract

International audience; Cognitive theories have been proposed to clarify the causes and symptoms of dyslexia. However, correlations between local network parameters of white matter connectivity and literacy skills remain poorly known. An unbiased hypothesis-free approach was adopted to examine the correlations between literacy symptoms (reading and spelling) and hub-based white matter networks' connectivity parameters [nodal degree fractional anisotropy (FA) values] of 90 brain regions based on Anatomical Atlas Labels (AAL) in a group of French children with dyslexia aged 9–14 years. Results revealed that the higher the right fusiform gyrus's (FFG) nodal degree FA values, the lower the reading accuracy for words and pseudowords in dyslexic children. The results indicate that the severity of word/pseudoword reading symptoms in dyslexia relates to a white matter network centered around the right FFG. The negative correlation between right FFG network connectivity and reading accuracy, in particular pseudoword reading accuracy, suggests that right FFG represents a maladaptive compensation towards a general orthography-to-phonology decoding ability in developmental dyslexia.

Details

Language :
English
ISSN :
00109452
Database :
OpenAIRE
Journal :
Cortex, Cortex, Elsevier, 2021, 145, pp.57-66. ⟨10.1016/j.cortex.2021.07.016⟩
Accession number :
edsair.doi.dedup.....f69414d57f3391c59e89495624bca9b8