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Th-1 and Th-2 cytokine production in infants with virus-associated wheezing
- Source :
- Brazilian Journal of Medical and Biological Research, Volume: 38, Issue: 1, Pages: 51-54, Published: JAN 2005, Scopus-Elsevier, ResearcherID, Brazilian Journal of Medical and Biological Research, Vol 38, Iss 1, Pp 51-54 (2005)
- Publication Year :
- 2005
- Publisher :
- Associação Brasileira de Divulgação Científica, 2005.
-
Abstract
- Wheezing associated with respiratory viral infections in infancy is very common and results in high morbidity worldwide. The Th1/Th2 pattern of immune response in these patients remains unclear and previous studies have shown controversial results. The aim of the present study was to compare the type of Th1/Th2 cytokine response between infants with acute bronchiolitis, recurrent wheezing and upper respiratory infections from a developing country. Infants younger than 2 years of age admitted to Hospital São Lucas, Porto Alegre, RS, Brazil, between May and November 2001, with an acute episode of wheezing associated with viral respiratory infection were selected. Subjects with upper respiratory infections from the emergency department were selected for the control group. Interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) levels from nasal aspirates were determined by ELISA from peripheral mononuclear cell cultures. Twenty-nine subjects with acute bronchiolitis, 18 with recurrent wheezing and 15 with upper respiratory infections were enrolled. There were no differences in family history of atopy or parental smoking between groups. Oxygen requirement was similar for the acute bronchiolitis and recurrent wheezing groups. The percentage of positive tests for the cytokines studied and the IFN-gamma/IL-4 ratio was similar for all groups. Comparison of the polarized Th1/Th2 cytokine results for the various groups showed no specific pattern of cytokine production. Infants with wheezing from a developing country do not show any specific predominant pattern of Th1/Th2 cytokine production, suggesting that multiple factors may be involved in the pathogenesis of this illness.
- Subjects :
- Male
Physiology
medicine.medical_treatment
Immunology
Biophysics
Enzyme-Linked Immunosorbent Assay
Biochemistry
Virus
Pathogenesis
Atopy
Interferon-gamma
Immune system
Th2 Cells
medicine
Bronchiolitis, Viral
Humans
Acute bronchiolitis
General Pharmacology, Toxicology and Pharmaceutics
Family history
Respiratory system
lcsh:QH301-705.5
Respiratory Tract Infections
Respiratory Sounds
Inflammation
lcsh:R5-920
business.industry
General Neuroscience
Infant
Cell Biology
General Medicine
Emergency department
Th1 Cells
medicine.disease
Nasal Lavage Fluid
Cytokine
lcsh:Biology (General)
Virus Diseases
Case-Control Studies
Acute Disease
Cytokines
Female
Interleukin-4
business
lcsh:Medicine (General)
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Brazilian Journal of Medical and Biological Research, Volume: 38, Issue: 1, Pages: 51-54, Published: JAN 2005, Scopus-Elsevier, ResearcherID, Brazilian Journal of Medical and Biological Research, Vol 38, Iss 1, Pp 51-54 (2005)
- Accession number :
- edsair.doi.dedup.....f75b9adca36cefe282a01131334a7085