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Is antithrombin treatment of disseminated intravascular coagulation a quixotic goal?
- Source :
- Critical Care. 18
- Publication Year :
- 2014
- Publisher :
- Springer Science and Business Media LLC, 2014.
-
Abstract
- The development of disseminated intravascular coagulation (DIC) is associated with increased sepsis mortality. Antithrombin (AT) is one of several anticoagulants that have been studied in randomized trials of sepsis without benefit. In a recent study, Iba and colleagues reviewed data from patients who were treated for sepsis-related DIC with two lower doses of AT concentrate than studied in prior trials. Patients received 1,500 IU/day (n = 259) or 3,000 IU/day (n = 48) of AT for 3 days. All patients had baseline antithrombin activity
- Subjects :
- Disseminated intravascular coagulation
medicine.medical_specialty
business.industry
Sepsis mortality
Confounding
Antithrombin
Antithrombin Activity
Critical Care and Intensive Care Medicine
medicine.disease
Placebo group
Surgery
law.invention
Sepsis
Randomized controlled trial
law
Internal medicine
medicine
business
medicine.drug
Subjects
Details
- ISSN :
- 13648535
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Critical Care
- Accession number :
- edsair.doi.dedup.....f7920dbe7d0b916a8b4b12da840ab594
- Full Text :
- https://doi.org/10.1186/s13054-014-0639-1