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T-cell costimulation blockade in immunologic diseases: role of CD28 family members
- Source :
- Expert review of clinical immunology. 3(3)
- Publication Year :
- 2010
-
Abstract
- The destruction of many immune-mediated diseases is a result of T-cell responses against usually harmless antigens. Extensive research has been conducted to discover new mechanisms to specifically modulate harmful effector T cells while leaving normal immune responses intact. Since proteins of the CD28 family members are expressed on T cells, blockade of these proteins has become a possible target for potential therapies. The CD28 family contains proteins that have the ability to both enhance and diminish T-cell responses. Therefore, blockade of targets that enhance T-cell signaling may reduce destructive autoimmune responses, while blockade of targets that diminish T-cell signaling may enhance antitumor responses. In this article, the function of these proteins will be reviewed and a sample of clinical trials highlighting the potential efficacy and drawbacks of their use in humans will be described briefly. Finally, inducible costimulator and programmed death-1, two future targets of T-cell therapies, will be highlighted.
Details
- ISSN :
- 17448409
- Volume :
- 3
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Expert review of clinical immunology
- Accession number :
- edsair.doi.dedup.....f79408ab23c8f11a937721df7f9f40a3