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Neuropeptide CGRP limits group 2 innate lymphoid cell responses and constrains type 2 inflammation
- Source :
- Immunity
- Publication Year :
- 2019
-
Abstract
- Innate lymphocytes maintain tissue homeostasis at mucosal barriers, with group 2 innate lymphoid cells (ILC2s) producing type 2 cytokines and controlling helminth infection. While the molecular understanding of ILC2 responses has advanced, the complexity of microenvironmental factors impacting ILC2s is becoming increasingly apparent. Herein, we used single-cell analysis to explore the diversity of gene expression among lung lymphocytes during helminth infection. Following infection, we identified a subset of ILC2s that preferentially expressed Il5-encoding interleukin (IL)-5, together with Calca-encoding calcitonin gene-related peptide (CGRP) and its cognate receptor components. CGRP in concert with IL-33 and neuromedin U (NMU) supported IL-5 but constrained IL-13 expression and ILC2 proliferation. Without CGRP signaling, ILC2 responses and worm expulsion were enhanced. Collectively, these data point to CGRP as a context-dependent negative regulatory factor that shapes innate lymphocyte responses to alarmins and neuropeptides during type 2 innate immune responses.
- Subjects :
- 0301 basic medicine
Innate immune system
Lymphocyte
Immunology
Innate lymphoid cell
Interleukin
Inflammation
Calcitonin gene-related peptide
Biology
Article
Interleukin 33
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Infectious Diseases
medicine.anatomical_structure
030220 oncology & carcinogenesis
medicine
Immunology and Allergy
medicine.symptom
Tissue homeostasis
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Immunity
- Accession number :
- edsair.doi.dedup.....f79a323e431b0d9fce7d4718389926ed