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Aberrant expression of pyloric gland-type mucin in mucin-producing bile duct carcinomas: a clear difference between the core peptide and the carbohydrate moiety
- Source :
- Pathology international. 55(8)
- Publication Year :
- 2005
-
Abstract
- The authors have recently defined the clinopathological entity of a mucin-producing bile duct tumor (MPBT), and divided MPBT into two distinct subtypes: ‘columnar-type’ and ‘cuboidal-type’ MPBT. Mucin core protein 6 (MUC6), which is present in normal pyloric glands, had higher expression levels in cuboidal-type tumors than in columnar-type tumors. In the pyloric glands, a carbohydrate antigen detected by monoclonal antibody HIK1083 (CA/HIK1083) is also expressed. In order to evaluate the coexpression pattern of MUC6 and CA/HIK1083 in MPBT, expression profiles were evaluated in 38 surgically excised mucin-producing bile duct carcinomas (MPBC; cuboidal-type, n = 15; columnar-type, n = 23), using immunohistochemistry. The staining rate was graded as follows: –
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
medicine.drug_class
Carbohydrates
Bile Duct Neoplasm
Biology
Monoclonal antibody
Pathology and Forensic Medicine
Bile Ducts, Extrahepatic
Internal medicine
medicine
Humans
Antigens, Tumor-Associated, Carbohydrate
Mucin-6
Aged
Aged, 80 and over
Bile duct
Mucin
Mucins
Antibodies, Monoclonal
General Medicine
Carbohydrate moiety
Middle Aged
Adenocarcinoma, Mucinous
Immunohistochemistry
Staining
medicine.anatomical_structure
Endocrinology
Bile Duct Neoplasms
Gastric Mucosa
Core peptide
Female
Peptides
Subjects
Details
- ISSN :
- 13205463
- Volume :
- 55
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Pathology international
- Accession number :
- edsair.doi.dedup.....f79a6bbc3820714c15fb58ef6bb41ba7