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Signaling proteins that regulate NaCL chemotaxis responses modulate longevity in C. elegans
- Source :
- International Symposium on Olfaction and Taste, 682-687, STARTPAGE=682;ENDPAGE=687;TITLE=International Symposium on Olfaction and Taste
- Publication Year :
- 2009
- Publisher :
- The New York academy of sciences, 2009.
-
Abstract
- The lifespan of the nematode Caenorhabditis elegans is regulated by sensory signals detected by the amphid neurons. In these neurons, C. elegans expresses at least 14 Gα subunits and a Gγ subunit. We have identified seven sensory Gα subunits that modulate lifespan. Genetic experiments suggest that multiple sensory signaling pathways exist that modulate lifespan and that some G proteins function in multiple pathways, most of which, but probably not all, involve insulinIGF-1 like signaling. Interestingly, of the sensory G proteins involved in regulating lifespan, only one Gα probably functions directly in the detection of sensory cues. The other G proteins seem to function in modulating the sensitivity of the sensory neurons. We hypothesize that in addition to the mere detection of sensory cues, regulation of the sensitivity of sensory neurons also plays a role in the regulation of lifespan.
- Subjects :
- G protein
General Neuroscience
Protein subunit
Chemotaxis
Longevity
Amphid
Sensory system
Biology
Sodium Chloride
Heterotrimeric GTP-Binding Proteins
General Biochemistry, Genetics and Molecular Biology
Cell biology
History and Philosophy of Science
Taste
Animals
Signal transduction
Caenorhabditis elegans
Sensory cue
Function (biology)
Signal Transduction
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- International Symposium on Olfaction and Taste, 682-687, STARTPAGE=682;ENDPAGE=687;TITLE=International Symposium on Olfaction and Taste
- Accession number :
- edsair.doi.dedup.....f7ae1d04c60e126d99ba9055f11b7f52