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The human Mediator complex: a versatile, genome-wide regulator of transcription
- Source :
- Trends in Biochemical Sciences. 35:315-322
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- The Mediator complex interacts extensively with the RNA polymerase II enzyme and regulates its ability to express protein-coding genes. The mechanisms by which Mediator regulates gene expression remain poorly understood, in part because the structure of Mediator and even its composition can change, depending upon the promoter context. Combined with the sheer size of the human Mediator complex (26 subunits, 1.2 MDa), this structural adaptability bestows seemingly unlimited regulatory potential within the complex. Recent efforts to understand Mediator structure and function have identified expanded roles that include control of both pre- and post-initiation events; it is also evident that Mediator performs both general and gene-specific roles to regulate gene expression.
- Subjects :
- Genetics
Regulation of gene expression
Mediator Complex
Transcription, Genetic
General transcription factor
RNA polymerase II
Biology
Biochemistry
Article
MED12
MED1
Cell biology
Upstream activating sequence
Mediator
Gene Expression Regulation
biology.protein
Animals
Humans
Molecular Biology
Transcription factor
Transcription Factors
Subjects
Details
- ISSN :
- 09680004
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Trends in Biochemical Sciences
- Accession number :
- edsair.doi.dedup.....f7b7e2b3a59bdecee7e5860bf5edcbe8