Treatment of atherosclerosis obliterans with pyridinolcarbamate

One hundred and eighty patients with atherosclerosis obliterans were treated with pyridinolcarbamate for 5 to 225 weeks (mean 44.9 weeks).1) Clinical symptoms and signs were improved by this treatment: intermittent claudication was improved in 50.9% of the total number of cases. Cyanosis disappeared in 37.9%. Paresthesia disappeared in 83.5%. Ulcers were healed in 84.0%. Pulse wave reappeared in plethy-smogram in 44%. Crest time was shortened in 18% of the total number of cases.2) During a treatment period of 3 years almost of the all cases with symptoms of intermittent claudication, cyanosis, paresthesia and finding of crest time that were improved had improved within 20 weeks.Pain, ulcer and appearance of pulse waves in plethysmograms were also improved in more than half of all patients within 30 weeks, however, in a few cases, it took more than 30 weeks to cure and to improve these symptoms.3) From the above results, it was concluded that pyridinolcarbamate treatment should be tried for 20 to 30 weeks as the first stage of the treat-ment and subsequently continue for 1 year even though clinical symptoms may not improve. It should also be tried for longer periods to prevent other complications resulting from atherosclerosis.