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Analysis of HYAL3 gene mutations in Chinese lung squamous cell carcinoma patients
- Source :
- Tumori. 99(1)
- Publication Year :
- 2013
-
Abstract
- PurposeIn a previous study, we found a hyaluronidase 3 (HYAL3) gene mutation in exon 2 at position 188 by genome sequencing in a lung squamous cell carcinoma patient. The mutation results in substitution of serine for alanine. The aim of the study was to screen the HYAL3 gene mutation in Chinese lung squamous cell carcinoma patients and explore the correlation between mutation of HYAL3 with clinical and pathological characteristics in lung squamous cell carcinoma patients in China.MethodsWe applied polymerase chain reaction to examine the HYAL3 gene mutations in cancer tissues and their adjacent normal tissues from 39 cases of lung squamous cell carcinoma patients.Results1) The incidence rate of HYAL3 mutation in 39 cases of lung squamous cell carcinoma was 10.26% (4/39) and none in adjacent normal lung tissues (0/39). 2) The mutations of HYAL3 in the 4 cases were all heterozygous: 3 of them were located in exon 1 (G-T) and one in exon 2 (G-T). 3) Mutations of the HYAL3 gene were not correlated with the distribution of patient gender, age, tumor size, histological grade, smoking history, TNM stage or distant metastasis ( P >0.05). The gene mutation was correlated with lymph node status ( P = 0.044).ConclusionMutations of the HYAL3 gene are rare in Chinese lung squamous cell carcinoma patients and might contribute to lymph node metastasis.
- Subjects :
- Male
Cancer Research
China
Lung Neoplasms
Hyaluronoglucosaminidase
Polymerase Chain Reaction
03 medical and health sciences
0302 clinical medicine
Asian People
Humans
030212 general & internal medicine
Aged
Neoplasm Staging
Aged, 80 and over
Smoking
General Medicine
Exons
Middle Aged
Oncology
030220 oncology & carcinogenesis
Lymphatic Metastasis
Mutation
Carcinoma, Squamous Cell
Female
Neoplasm Grading
Cell Adhesion Molecules
Subjects
Details
- ISSN :
- 20382529
- Volume :
- 99
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Tumori
- Accession number :
- edsair.doi.dedup.....f7c1e11af61c9f26e5d4b71533ab56d3