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Anti-obesity drug discovery: advances and challenges
- Source :
- Nature Reviews-Drug Discovery, Nature Reviews. Drug Discovery
-
Abstract
- Enormous progress has been made in the last half-century in the management of diseases closely integrated with excess body weight, such as hypertension, adult-onset diabetes and elevated cholesterol. However, the treatment of obesity itself has proven largely resistant to therapy, with anti-obesity medications (AOMs) often delivering insufficient efficacy and dubious safety. Here, we provide an overview of the history of AOM development, focusing on lessons learned and ongoing obstacles. Recent advances, including increased understanding of the molecular gut–brain communication, are inspiring the pursuit of next-generation AOMs that appear capable of safely achieving sizeable and sustained body weight loss.<br />The development of therapies that are capable of safely achieving sizeable and sustained body weight loss has proved tremendously challenging. Here, Müller et al. provide an overview of the history of anti-obesity drug development, focusing on lessons learned, ongoing challenges and recent advances in the field.
- Subjects :
- Adult
Pharmacology
medicine.medical_specialty
business.industry
Diabetes
MEDLINE
Review Article
General Medicine
Body weight
medicine.disease
Obesity
Diabetes Mellitus, Type 2
Diabetes mellitus
Anti obesity
Weight Loss
Drug Discovery
otorhinolaryngologic diseases
medicine
Humans
Anti-Obesity Agents
Intensive care medicine
business
Subjects
Details
- Language :
- English
- ISSN :
- 14741784 and 14741776
- Volume :
- 21
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Nature Reviews Drug Discovery
- Accession number :
- edsair.doi.dedup.....f7c9dd903f24e0e6a0d1a00c7cad5fcf
- Full Text :
- https://doi.org/10.1038/s41573-021-00337-8