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The Dual Blockade in the Neoadjuvant Setting of HER-2 Positive Early-Stage Breast Cancer
- Source :
- Journal of Medicine and Life
- Publication Year :
- 2019
- Publisher :
- S.C. JURNALUL PENTRU MEDICINA SI VIATA S.R.L, 2019.
-
Abstract
- Patients with positive Her-2/neu breast cancer and a high risk of recurrence are known to benefit from the addition of the dual blockade of Her-2/neu with Trastuzumab and Pertuzumab to the neoadjuvant chemotherapy, a combination which has been demonstrated to give a higher rate of a complete pathologic response in the breast and in the axilla. The purpose of this review is to outline the efficacy of the dual blockade with Trastuzumab and Pertuzumab in the neoadjuvant treatment of high-risk Her-2 positive breast cancer. Electronic databases (Pubmed, Medline, and Cochrane Database of Systematic Reviews) were searched for English- and German-language studies, which were published in the last ten years. The search has been focused on neoadjuvant clinical trials as well as on the data presented in the abstracts published at the San Antonio Breast Cancer Symposium as well as at the annual meeting of the American Society of Clinical Oncology. The results reported in the published clinical trials demonstrated a higher pathologic complete response rate in breast and lymph nodes after using targeted therapy with two anti-Her-2/neu agents - Trastuzumab and Pertuzumab in combination with neoadjuvant chemotherapy for early-stage Her-2/neu positive breast cancers. The pathologic complete response rate is the most important prognostic marker in Her-2/neu positive tumors, a higher pathologic complete response rate being demonstrated to be associated with a better survival outcome in terms of higher overall survival and disease-free survival rates.
- Subjects :
- Oncology
medicine.medical_specialty
dual blockade
Receptor, ErbB-2
medicine.medical_treatment
Breast Neoplasms
Review
Disease-Free Survival
Targeted therapy
Breast cancer
Trastuzumab
Internal medicine
medicine
Humans
Stage (cooking)
skin and connective tissue diseases
Neoplasm Staging
Chemotherapy
Pertuzumab
business.industry
neoadjuvant
General Medicine
medicine.disease
Neoadjuvant Therapy
Clinical trial
Axilla
medicine.anatomical_structure
Female
Lymph Nodes
business
medicine.drug
Subjects
Details
- ISSN :
- 18443117 and 1844122X
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Journal of Medicine and Life
- Accession number :
- edsair.doi.dedup.....f7d119b883c0509e6f91b4c45415a120