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Does donor–recipient ABO incompatibility protect against relapse after allogeneic bone marrow transplantation in first remission acute myeloid leukemia?
- Source :
- Bone Marrow Transplantation. 29:853-859
- Publication Year :
- 2002
- Publisher :
- Springer Science and Business Media LLC, 2002.
-
Abstract
- It is not known if donor-recipient ABO blood group incompatibility contributes to graft-versus-leukemia after allogeneic BMT. One hundred and nineteen patients with acute myeloid leukemia in first remission underwent non-T cell-depleted marrow allografts from HLA-identical siblings after TBI and cyclophosphamide (n = 72) or melphalan (n = 47). GVHD prophylaxis comprised cyclosporine alone or cyclosporine-methotrexate. Twenty-two patients relapsed at 3-46 months (median 7): 18 of 76 patients with ABO-matched donors and four of 43 patients with ABO-mismatched donors (actuarial 5-year probabilities 33 +/- 6% vs 12 +/- 6%; P = 0.028). The incidence of acute and chronic GVHD was not affected by ABO mismatch. The following factors were studied in Cox analysis for effect on outcome: gender, age, FAB subtype, ABO mismatch, CR-transplant interval, conditioning, TBI dose, nucleated cell dose, lymphocyte recovery, acute GVHD, and chronic GVHD. Donor-recipient ABO match was the only factor independently associated with a higher risk of relapse (RR = 3.7; 95% Cl, 1.1-12.6; P = 0.04). ABO mismatch was also associated with superior overall and disease-free survivals. We conclude that ABO incompatibility may influence relapse rates and survival favorably after allogeneic BMT. It is not known if this holds true for allogeneic blood stem cell transplants.
- Subjects :
- Adult
Male
Melphalan
medicine.medical_specialty
Myeloid
Adolescent
Cyclophosphamide
Gastroenterology
ABO Blood-Group System
hemic and lymphatic diseases
Internal medicine
ABO blood group system
parasitic diseases
medicine
Humans
Transplantation, Homologous
Bone Marrow Transplantation
Transplantation
business.industry
Remission Induction
Myeloid leukemia
Hematology
Middle Aged
medicine.disease
Tissue Donors
Leukemia, Myeloid, Acute
Leukemia
surgical procedures, operative
medicine.anatomical_structure
Histocompatibility
Immunology
Female
Bone marrow
Erythrocyte Transfusion
business
medicine.drug
Subjects
Details
- ISSN :
- 14765365 and 02683369
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Bone Marrow Transplantation
- Accession number :
- edsair.doi.dedup.....f7d1c0a75d21ea4c6f3ff3c11a49d145