Back to Search
Start Over
TP53 in Myelodysplastic Syndromes: Recent Biological and Clinical Findings
- Source :
- International Journal of Molecular Sciences, Vol 21, Iss 3432, p 3432 (2020), International Journal of Molecular Sciences
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- TP53 dysregulation plays a pivotal role in the molecular pathogenesis of myelodysplastic syndromes (MDS), identifying a subgroup of patients with peculiar features. In this review we report the recent biological and clinical findings of TP53-mutated MDS, focusing on the molecular pathways activation and on its impact on the cellular physiology. In MDS, TP53 mutational status is deeply associated with del(5q) syndrome and its dysregulation impacts on cell cycle, DNA repair and apoptosis inducing chromosomal instability and the clonal evolution of disease. TP53 defects influence adversely the MDS clinical outcome and the treatment response rate, thus new therapeutic approaches are being developed for these patients. TP53 allelic state characterization and the mutational burden evaluation can therefore predict prognosis and identify the subgroup of patients eligible for targeted therapy. For these reasons, in the era of precision medicine, the MDS diagnostic workup cannot do without the complete assessment of TP53 mutational profile.
- Subjects :
- 0301 basic medicine
p53 expression
DNA repair
medicine.medical_treatment
Review
Disease
Bioinformatics
Somatic evolution in cancer
Catalysis
Targeted therapy
Inorganic Chemistry
lcsh:Chemistry
03 medical and health sciences
0302 clinical medicine
TP53 mutation, p53 expression, myelodysplastic syndrome, del(5q), prognosis, target therapy
Chromosome instability
hemic and lymphatic diseases
del(5q)
Medicine
Physical and Theoretical Chemistry
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
target therapy
business.industry
Myelodysplastic syndromes
Organic Chemistry
TP53 mutation
General Medicine
Cell cycle
medicine.disease
Precision medicine
myelodysplastic syndrome
Computer Science Applications
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
030220 oncology & carcinogenesis
prognosis
business
Subjects
Details
- Language :
- English
- ISSN :
- 16616596 and 14220067
- Volume :
- 21
- Issue :
- 3432
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....f7d4499d205d2cd3c7ea123233eba203