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Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas
- Source :
- Frontiers of Medicine
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- Viral infections cause at least 10%-15% of all human carcinomas. Over the last century, the elucidation of viral oncogenic roles in many cancer types has provided fundamental knowledge on carcinogenetic mechanisms and established a basis for the early intervention of virus-related cancers. Meanwhile, rapidly evolving genome-editing techniques targeting viral DNA/RNA have emerged as novel therapeutic strategies for treating virus-related carcinogenesis and have begun showing promising results. This review discusses the recent advances of genome-editing tools for treating tumorigenic viruses and their corresponding cancers, the challenges that must be overcome before clinically applying such genome-editing technologies, and more importantly, the potential solutions to these challenges.
- Subjects :
- 0301 basic medicine
genome-editing tools
viruses
delivery method
Review
Biology
medicine.disease_cause
Antiviral Agents
Virus
03 medical and health sciences
Genome editing
medicine
Humans
Genetic Predisposition to Disease
Dna viral
Virus-Related Carcinoma
off-target effect
Gene Editing
Carcinoma
RNA
Cancer
Genetic Therapy
General Medicine
medicine.disease
Tumor Virus Infections
030104 developmental biology
Medicine public health
tumorigenic virus
Cancer research
CRISPR-Cas Systems
virus-related carcinoma
Carcinogenesis
Subjects
Details
- ISSN :
- 20950225 and 20950217
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Frontiers of Medicine
- Accession number :
- edsair.doi.dedup.....f7d572b3f572d8cdc52af6fec37b183e
- Full Text :
- https://doi.org/10.1007/s11684-017-0572-1