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Endocannabinoids in immune regulation and immunopathologies
- Source :
- Immunology
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Endocannabinoids are key bioactive components of the endocannabinoid system, and the profound influence of endocannabinoids on the modulation of the immune system is being increasingly appreciated. The knowledge of endocannabinoid–immune cell crosstalk will pave the way to therapeutic implications of modulators of this pathway in autoimmune and chronic inflammatory disorders. Endocannabinoids seem to exert both anti‐inflammatory and pro‐inflammatory effects in specific contexts, based on specific receptor engagement and the downstream signalling pathways involved. In this review, we summarized the biosynthesis, signalling and degradation of two well‐studied endocannabinoids—anandamide and 2‐arachidonylglycerol in immune cells. Then, we discussed the effects of these two endocannabinoids on the functioning of major innate and adaptive immune cells, along with the choice of receptors employed in such interactions. Finally, we outline our current knowledge on the involvement of anandamide and 2‐arachidonylglycerol in context of inflammation, allergies, autoimmunity and metabolic disorders.
- Subjects :
- Polyunsaturated Alkamides
Immunology
Reviews
Inflammation
Context (language use)
Arachidonic Acids
Adaptive Immunity
Biology
medicine.disease_cause
Glycerides
Autoimmunity
chemistry.chemical_compound
Immune system
medicine
Animals
Humans
Immunology and Allergy
Receptor
musculoskeletal, neural, and ocular physiology
Anandamide
Endocannabinoid system
Immunity, Innate
Crosstalk (biology)
nervous system
chemistry
lipids (amino acids, peptides, and proteins)
medicine.symptom
Neuroscience
psychological phenomena and processes
Endocannabinoids
Signal Transduction
Subjects
Details
- ISSN :
- 13652567 and 00192805
- Volume :
- 164
- Database :
- OpenAIRE
- Journal :
- Immunology
- Accession number :
- edsair.doi.dedup.....f7db5065df9b4dd4d9c0c00f04a444de