Cerebrospinal fluid fatty acids in glucocerebrosidase-associated Parkinson's disease

Background: Heterozygous mutations in the glucocer-ebrosidase gene lead to an increased risk for and tomore severe alpha-synuclein-associated pathology inParkinson’s disease. As both glucocerebrosidase andalpha-synuclein interact with fatty acids, we hypothe-sized that cerebrospinal fluid fatty acid levelsare altered in these Parkinson’s disease patients.Methods: Cerebrospinal fluid levels of 13 fatty acids in8 Parkinson’s disease patients with a heterozygousglucocerebrosidase mutation were compared withthose of 41 idiopathic Parkinson’s disease patients and ------------------------------------------------------------ Additional Supporting Information may be found in the online version ofthis article.Stefan P. Schmid and Erwin D. Schleicher contributed equally to thisarticle.*Correspondence to: Walter Maetzler, Department ofNeurodegeneration, University of Tuebingen, Germany, OtfriedMu¨ller-Strasse 27, 72076 Tuebingen, Germany; walter.maetzler@uni-tuebingen.deRelevant conflicts of interest/financial disclosures: Stefan Schmid issupported by a German National Genome Network Grant (NGFNplus01GS08134). Walter Maetzler is supported by a ForschungskollegGeriatrie Grant from the Robert Bosch Foundation, Stuttgart, Germany(Nr. 32.5.1141.0019.0).Full financial disclosures and author roles may be found in the onlineversion of this article.Received: 7 April 2011; Revised: 15 August 2011; Accepted: 25August 2011Published online 21 October 2011 in Wiley Online Library(wileyonlinelibrary.com). DOI: 10.1002/mds.23984SCHMID ET AL.