Back to Search
Start Over
Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila
- Source :
- eLife, Vol 6 (2017), Elife, eLife
- Publication Year :
- 2017
- Publisher :
- eLife Sciences Publications, Ltd, 2017.
-
Abstract
- Ageing is a progressive decline of intrinsic physiological functions. We examined the impact of ageing on the ultrastructure and function of mitochondria in mouse and fruit flies (Drosophila melanogaster) by electron cryo-tomography and respirometry. We discovered distinct age-related changes in both model organisms. Mitochondrial function and ultrastructure are maintained in mouse heart, whereas subpopulations of mitochondria from mouse liver show age-related changes in membrane morphology. Subpopulations of mitochondria from young and old mouse kidney resemble those described for apoptosis. In aged flies, respiratory activity is compromised and the production of peroxide radicals is increased. In about 50% of mitochondria from old flies, the inner membrane organization breaks down. This establishes a clear link between inner membrane architecture and functional decline. Mitochondria were affected by ageing to very different extents, depending on the organism and possibly on the degree to which tissues within the same organism are protected against mitochondrial damage. DOI: http://dx.doi.org/10.7554/eLife.24662.001
- Subjects :
- 0301 basic medicine
Aging
Mouse
peroxide radicals
QH301-705.5
Science
Mitochondrion
Biochemistry
DNA, Mitochondrial
respiratory activity
General Biochemistry, Genetics and Molecular Biology
Mice
03 medical and health sciences
Respirometry
Imaging, Three-Dimensional
0302 clinical medicine
ddc:590
membrane structure
Animals
Inner membrane
Biology (General)
Inner mitochondrial membrane
Tomography
Drosophila
D. melanogaster
General Immunology and Microbiology
biology
General Neuroscience
Cryoelectron Microscopy
General Medicine
Biophysics and Structural Biology
biology.organism_classification
mitochondrial inner membrane
Mitochondria
Cell biology
Drosophila melanogaster
030104 developmental biology
cryo-tomography
Organ Specificity
ageing
Ageing
Ultrastructure
Medicine
Energy Metabolism
030217 neurology & neurosurgery
Research Article
Subjects
Details
- ISSN :
- 2050084X
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- eLife
- Accession number :
- edsair.doi.dedup.....f7e903013316c1319c9fc3fef398a73c