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The genetic architecture of schizophrenia, bipolar disorder, obsessive-compulsive disorder and autism spectrum disorder
- Source :
- Molecular and cellular neurosciences. 88
- Publication Year :
- 2017
-
Abstract
- Considerable evidence suggests that autism spectrum disorders (ASD), schizophrenia (SCZ), bipolar disorder (BD) and obsessive-compulsive disorder (OCD) share a common molecular aetiology, despite their unique clinical diagnostic criteria. The aim of this study was therefore to determine and characterise the common and unique molecular architecture of ASD, SCZ, BD and OCD. Gene lists were obtained from previously published studies for ASD, BD, SCZ and for OCD. Genes identified to be common to all disorders, or unique to one specific disorder, were included for enrichment analyses using the web-server tool Enrichr. Ten genes were identified to be commonly associated with the aetiology of ASD, SCZ, BD and OCD. Enrichment analyses determined that these genes are predominantly involved in the dopaminergic and serotonergic pathways, the voltage-gated calcium ion channel gene network, folate metabolism, regulation of the hippo signaling pathway, and the regulation of gene silencing and expression. In addition to well-characterised and previously described pathways, regulation of the hippo signaling pathway was commonly associated with ASD, SCZ, BD and OCD, implicating neural development and neuronal maintenance as key in neuropsychiatric disorders. In contrast, a large number of previously associated genes were shown to be disorder-specific. And unique disorder-specific pathways and biological processes were presented for ASD, BD, SCZ and OCD aetiology. Considering the current global incidence and prevalence rates of mental health disorders, focus should be placed on cross-disorder commonalities in order to realise actionable and translatable results to combat mental health disorders.
- Subjects :
- 0301 basic medicine
Obsessive-Compulsive Disorder
Bipolar Disorder
Autism Spectrum Disorder
Gene Expression
Biology
behavioral disciplines and activities
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
mental disorders
medicine
Humans
Genetic Predisposition to Disease
Bipolar disorder
Molecular Biology
Psychiatric genetics
Hippo signaling pathway
Cell Biology
medicine.disease
Mental illness
Genetic architecture
030104 developmental biology
Autism spectrum disorder
Schizophrenia
Autism
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 10959327
- Volume :
- 88
- Database :
- OpenAIRE
- Journal :
- Molecular and cellular neurosciences
- Accession number :
- edsair.doi.dedup.....f7eefe0fb71c374b16e6a43674202170