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Mucins, gut microbiota, and postbiotics role in colorectal cancer
- Source :
- Gut Microbes, article-version (VoR) Version of Record, Gut Microbes, Vol 13, Iss 1 (2021)
- Publication Year :
- 2021
-
Abstract
- An imbalance in the crosstalk between the host and gut microbiota affects the intestinal barrier function, which results in inflammatory diseases and colorectal cancer. The colon epithelium protects itself from a harsh environment and various pathogenic organisms by forming a double mucus layer, primarily comprising mucins. Recent studies are focusing on how dietary patterns alter the gut microbiota composition, which in turn regulates mucin expression and maintains the intestinal layers. In addition, modulation of gut microbiota by microbiotic therapy (involving fecal microbiota transplantation) has emerged as a significant factor in the pathologies associated with dysbiosis. Therefore, proper communication between host and gut microbiota via different dietary patterns (prebiotics and probiotics) is needed to maintain mucus composition, mucin synthesis, and regulation. Here, we review how the interactions between diet and gut microbiota and bacterial metabolites (postbiotics) regulate mucus layer functionalities and mucin expression in human health and disease.
- Subjects :
- Microbiology (medical)
Colorectal cancer
colorectal cancer
RC799-869
Review
Gut flora
Microbiology
digestive system
fluids and secretions
medicine
Animals
Humans
Intestinal Mucosa
Barrier function
postbiotics
biology
gut microbiota
Probiotics
Mucin
Gastroenterology
Mucins
Fecal bacteriotherapy
Diseases of the digestive system. Gastroenterology
medicine.disease
biology.organism_classification
Mucus
Gastrointestinal Microbiome
Crosstalk (biology)
Infectious Diseases
Prebiotics
Colorectal Neoplasms
Dysbiosis
Subjects
Details
- ISSN :
- 19490984
- Volume :
- 13
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Gut microbes
- Accession number :
- edsair.doi.dedup.....f7f94518fcff74dd6f31c0c22e3f1a6b