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The mitochondrial and death receptor pathways involved in the thymocytes apoptosis induced by aflatoxin B1
- Source :
- Oncotarget
- Publication Year :
- 2016
- Publisher :
- Impact Journals LLC, 2016.
-
Abstract
- Aflatoxin B1 (AFB1) is a potent immunosuppressive agent in endotherms, which can be related to the up-regulated apoptosis of immune organs. In this study, we investigated the roles of the mitochondrial, death receptor, and endoplasmic reticulum pathways in Aflatoxin B1 induced thymocytes apoptosis. Chickens were fed an aflatoxin B1 containing diet (0.6 mg/kg AFB1) for 3 weeks. Our results showed that (1) AFB1 diet induced the decrease of T-cell subsets, morphological changes, and excessive apoptosis of thymus. (2) The excessive apoptosis involved the mitochondrial pathway (up-regulation of Bax, Bak, cytC and down-regulation of Bcl-2 and Bcl-xL) and death receptor pathway (up-regulation of FasL, Fas and FADD). (3) Oxidative stress, an apoptosis inducer, was confirmed in the thymus. In conclusion, this is the first study to demonstrate that mitochondrial and death receptor pathways involved in AFB1 induced thymocytes apoptosis in broilers.
- Subjects :
- 0301 basic medicine
Aflatoxin B1
medicine.disease_cause
Endoplasmic Reticulum
Fas ligand
03 medical and health sciences
Random Allocation
0302 clinical medicine
medicine
Animals
FADD
Immune response
Receptor
Thymocytes
biology
broilers
Endoplasmic reticulum
Research Paper: Immunology
apoptosis
Immunity
Receptors, Death Domain
Fas receptor
signaling pathways
Cell biology
Mitochondria
030104 developmental biology
Oncology
Apoptosis
030220 oncology & carcinogenesis
Immunology
biology.protein
Immunology and Microbiology Section
Signal transduction
Chickens
Oxidative stress
Subjects
Details
- Language :
- English
- ISSN :
- 19492553
- Volume :
- 7
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Oncotarget
- Accession number :
- edsair.doi.dedup.....f8033b3252478ca0ac5b8037bc897908