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Lipidâlowering effect of Pinus sp. sawdust and Pycnoporus sanguineus mycelium in streptozotocinâinduced diabetic rats
- Source :
- Journal of Food Biochemistry. 44
- Publication Year :
- 2020
- Publisher :
- Hindawi Limited, 2020.
-
Abstract
- The purpose of this study was to investigate the effect of diet supplementations on biochemical, hematological, and redox metabolism parameters in streptozotocin-induced diabetic rats. Healthy male Wistar rats and streptozotocin-induced diabetic rats were provided diets supplemented with 20% of Pinus sp. sawdust or Pycnoporus sanguineus mycelium for 4 weeks. Diabetic rats treated with both Pinus sp. sawdust- and P. sanguineus mycelium-supplemented diets presented a significant decrease in non-HDL cholesterol of 38.43% and 33.53% and triglycerides of 70.03% and 69.81%, respectively, compared to diabetic control. As far as we know, this is the first report of a significant decrease in serum lipids attributed to these supplementations. Even though with the alterations in hematological and redox metabolism parameters related to these diet treatments, our data suggest that Pinus sp. sawdust and Pycnoporus sanguineus mycelium could be a useful a diet supplement to control diabetic dyslipidemia in animals. PRACTICAL APPLICATIONS: Pinus sp. sawdust is a residue from the wood industry that can be reused as a substrate to cultivate Pycnoporus sanguineus mycelium. Both species have specific and rich natural compounds. The results of the present study surprisingly showed that diets supplemented with the isolated substrate (Pinus sp. sawdust) and Pycnoporus sanguineus mycelium significantly decrease non-HDL cholesterol and triglycerides in induced diabetic animal model. These new natural approaches can be interesting to develop a nutraceutical to treat dyslipidemia.
- Subjects :
- Male
030309 nutrition & dietetics
Biophysics
Blood lipids
Streptozocin
Diabetes Mellitus, Experimental
Polyporaceae
03 medical and health sciences
chemistry.chemical_compound
0404 agricultural biotechnology
Nutraceutical
medicine
Animals
Food science
Rats, Wistar
Pycnoporus sanguineus
Mycelium
Pharmacology
0303 health sciences
biology
Chemistry
Cholesterol
fungi
04 agricultural and veterinary sciences
Cell Biology
Pinus
medicine.disease
biology.organism_classification
Streptozotocin
Lipids
Wood
040401 food science
Pycnoporus
Rats
visual_art
visual_art.visual_art_medium
Sawdust
Dyslipidemia
Food Science
medicine.drug
Subjects
Details
- ISSN :
- 17454514 and 01458884
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Journal of Food Biochemistry
- Accession number :
- edsair.doi.dedup.....f807a085036839cc47b6159b06ad7ab8