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Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 in HIV infection: a single-arm substudy of a phase 2/3 clinical trial
- Source :
- The Lancet. HIV, e485, e474
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Background: data on vaccine immunogenicity against SARS-CoV-2 are needed for the 40 million people globally living with HIV who might have less functional immunity and more associated comorbidities than the general population. We aimed to explore safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine in people with HIV. Methods: in this single-arm open-label vaccination substudy within the protocol of the larger phase 2/3 trial COV002, adults aged 18–55 years with HIV were enrolled at two HIV clinics in London, UK. Eligible participants were required to be on antiretroviral therapy (ART), with undetectable plasma HIV viral loads (0·05 for all analyses). Interpretation: in this study of people with HIV, ChAdOx1 nCoV-19 was safe and immunogenic, supporting vaccination for those well controlled on ART. Funding: UK Research and Innovation, National Institutes for Health Research (NIHR), Coalition for Epidemic Preparedness Innovations, NIHR Oxford Biomedical Research Centre, Thames Valley and South Midland's NIHR Clinical Research Network, and AstraZeneca.
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
COVID-19 Vaccines
Epidemiology
Immunology
Population
HIV Infections
Antibodies, Viral
03 medical and health sciences
0302 clinical medicine
Oxford COVID Vaccine Trial Group
ChAdOx1 nCoV-19
Virology
Internal medicine
medicine
Humans
030212 general & internal medicine
education
Adverse effect
11 Medical and Health Sciences
education.field_of_study
SARS-CoV-2
business.industry
Immunogenicity
Comment
Vaccination
COVID-19
Articles
Middle Aged
030112 virology
CD4 Lymphocyte Count
Clinical trial
Infectious Diseases
Clinical research
Chills
medicine.symptom
business
Viral load
Subjects
Details
- ISSN :
- 23523018
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- The Lancet HIV
- Accession number :
- edsair.doi.dedup.....f81d522c70364195037ef2316c8812ad