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Inflammasome Activation Characterizes Lesional Skin of Folliculitis Decalvans
- Source :
- Acta Dermato-Venereologica, Vol 98, Iss 6, Pp 570-575 (2018)
- Publication Year :
- 2018
-
Abstract
- Folliculitis decalvans (FD) is a chronic inflammatory disease leading to scarring alopecia with poorly defined pathogenesis. The aim of this study was to investigate the expression of markers associated with the activation of innate immune signals, such as inflammasome (NALP1 and NALP3), interleukin (IL)-1β and IL-8 and type I interferon (MxA). A retrospective monocentric study was conducted and included 17 patients with FD with available biopsies. Disease activity (stable vs. active) was defined clinically and histologically. Immunostaining was performed using antibodies directed against NALP1, NALP3, IL-1β, IL-8, and MxA on FD skin biopsies. Results were compared with normal controls and lichen planopilaris. Eleven patients had active disease and 6 had stable disease. NALP1, NALP3, and IL-1β expression were significantly increased in hair follicles in FD compared with controls and lichen planopilaris. This study highlights the predominant immune signal associated with inflammasome activation in FD, suggesting the use of IL-1β blockade in FD.
- Subjects :
- Male
Myxovirus Resistance Proteins
Pathology
Inflammasomes
Biopsy
Interleukin-1beta
NALP3
Scarring alopecia
Pathogenesis
030207 dermatology & venereal diseases
0302 clinical medicine
lcsh:Dermatology
Medicine
treatment
biology
medicine.diagnostic_test
inflammasomeactivation
Interleukin
Inflammasome
General Medicine
Middle Aged
Immunohistochemistry
immunomodulatingtherapy
030220 oncology & carcinogenesis
Female
Folliculitis decalvans
Hair Follicle
medicine.drug
Adult
medicine.medical_specialty
NLR Proteins
Dermatology
03 medical and health sciences
Young Adult
Immune system
NLR Family, Pyrin Domain-Containing 3 Protein
Humans
Adaptor Proteins, Signal Transducing
Aged
Retrospective Studies
Folliculitis
Scalp
business.industry
Interleukin-8
folliculitisdecalvans
lcsh:RL1-803
medicine.disease
Scalp Dermatoses
cicatricialalopecia
biology.protein
business
Apoptosis Regulatory Proteins
Biomarkers
Subjects
Details
- ISSN :
- 16512057
- Volume :
- 98
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Acta dermato-venereologica
- Accession number :
- edsair.doi.dedup.....f83d0766c332fc0f3c144eebae54e67e