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The Effects of 4′-Esterified Resveratrol Derivatives on Calcium Dynamics in Breast Cancer Cells
- Source :
- Molecules, Vol 22, Iss 11, p 1968 (2017), Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry, Molecules; Volume 22; Issue 11; Pages: 1968
- Publication Year :
- 2017
- Publisher :
- MDPI AG, 2017.
-
Abstract
- Triple-negative breast cancer is a highly aggressive subtype of breast cancer. Frequently, breast cancer cells modulate their calcium signaling pathways to optimize growth. Unique calcium pathways in breast cancer cells could serve as a way to target tumorigenic cells without affecting normal tissue. Resveratrol has previously been shown to activate calcium signaling pathways. We use cell viability, single-cell calcium microscopy, and RT-PCR assays to determine the activity and mechanism of three different 4′-esterified resveratrol derivatives. We demonstrate that two of the derivatives reduce cell viability more effectively than resveratrol in MDA-MB-231 human breast cancer cells. The derivatives also activate similar pro-apoptotic calcium signaling pathways. In particular, the pivalated and butyrated resveratrol derivatives are intriguing putative chemotherapeutics because they are more effective at decreasing cell viability in vitro and inhibiting the plasma membrane Ca2+-ATPase, a protein that is often modulated in breast cancer.
- Subjects :
- p53
0301 basic medicine
MDA-MB-231
Pharmaceutical Science
Resveratrol
Analytical Chemistry
chemistry.chemical_compound
0302 clinical medicine
Stilbenes
Drug Discovery
skin and connective tissue diseases
Calcium signaling
Molecular Structure
Esters
Receptors, Estrogen
Biochemistry
Chemistry (miscellaneous)
030220 oncology & carcinogenesis
resveratrol derivatives
Molecular Medicine
Female
Cell Survival
chemistry.chemical_element
Antineoplastic Agents
Biology
Calcium
calcium signaling
Article
lcsh:QD241-441
03 medical and health sciences
Breast cancer
lcsh:Organic chemistry
Cell Line, Tumor
medicine
Humans
Viability assay
cell viability
Physical and Theoretical Chemistry
Cell Proliferation
Organic Chemistry
medicine.disease
In vitro
030104 developmental biology
chemistry
Cancer cell
Cancer research
Breast cancer cells
Subjects
Details
- ISSN :
- 14203049
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....f8578c0fcd5ecb2564e9de54ca23c599