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Long-term cetirizine treatment reduces allergic symptoms and drug prescriptions in children with mite allergy
- Source :
- Scopus-Elsevier
- Publication Year :
- 2001
- Publisher :
- Elsevier BV, 2001.
-
Abstract
- Experimental data demonstrate that mite allergy is characterized by persistent chronic inflammation, even during asymptomatic periods. This suggests that long-term continuous treatment be included in the global strategy of allergy treatment.We conducted a study to evaluate whether regularly administered cetirizine reduces allergic symptoms and drug prescriptions in children with mite allergy.In this double-blind, randomized, placebo-controlled study, two parallel groups of 10 children with mite allergy (mean age: 6.5 years) received either cetirizine or placebo daily for 6 months. Participants were allowed to take rescue medications for rhinitis and/or mild asthma. The symptoms (nasal itching, sneezing, obstruction, rhinorrhea, conjunctival itching, lacrimation, conjunctival hyperemia, cough, wheezing, and chest tightness) were recorded on a diary card. The intake of cetirizine (as additional symptomatic treatment), antibiotics, acetaminophen, beta2-agonists, inhaled and systemic corticosteroids was also recorded.Symptom scores and drug consumption were significantly lower (P0.05) in the cetrizine-treated group versus the placebo group. The greatest reductions were in cetirizine itself, inhaled corticosteroids, beta2-agonists, and antibiotics. No side effects were reported in either group.In mite-allergic children, cetirizine administered daily for prolonged periods decreases symptoms of and drug prescriptions for allergic rhinitis and asthma compared with symptomatic treatment.
- Subjects :
- Male
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Allergy
Time Factors
Immunology
Placebo
medicine.disease_cause
Asymptomatic
Allergen
Double-Blind Method
Internal medicine
Anti-Allergic Agents
Hypersensitivity
medicine
Animals
Humans
Immunology and Allergy
Child
Asthma
Mites
rhinorrhea
business.industry
Aeroallergen
Allergens
medicine.disease
Cetirizine
Treatment Outcome
Anesthesia
Female
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 10811206
- Volume :
- 87
- Database :
- OpenAIRE
- Journal :
- Annals of Allergy, Asthma & Immunology
- Accession number :
- edsair.doi.dedup.....f86288874e95f732cd54d88f84231631
- Full Text :
- https://doi.org/10.1016/s1081-1206(10)62230-2