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High Correlation between Glaucoma Treatment with Topical Prostaglandin Analogs and BDNF Immunoreactivity in Human Retina
- Source :
- Current Eye Research. 46:739-745
- Publication Year :
- 2020
- Publisher :
- Informa UK Limited, 2020.
-
Abstract
- To examine the expression of brain-derived neurotrophic factor (BDNF) and its high-affinity receptor, tropomyosin-related kinase receptor-B (TrkB), in normal and glaucomatous human retinas.Human retinas were collected from 8 donors who had been clinically diagnosed and treated for glaucoma, and from 9 control donors. Immunohistochemical analysis for BDNF and TrkB was performed. The percent of each retina expressing BDNF and TrkB was quantified for the total retinal thickness, and separately for the retinal ganglion cell (RGC) complex + retinal nerve fiber layer (RNFL). The expression of each protein was correlated with clinical outcomes obtained from the subject's ocular histories.There was no significant difference in BDNF or TrkB expression when comparing glaucomatous and control retinas. Correlation analysis revealed a significant relationship between BDNF expression and the use of prostaglandin analogs. TrkB expression was highly correlated with the last-measured intraocular pressure (IOP), the use of carbonic anhydrase inhibitors, the use of beta blockers, and the total number of drugs used for the treatment of glaucoma.Topical drugs used to treat glaucoma were associated with an increase in retinal BDNF and TrkB expression in human retina, independent of IOP, which may represent molecular evidence of neuroprotective pathway activation.
- Subjects :
- Male
Retinal Ganglion Cells
medicine.medical_specialty
Glaucoma
Administration, Ophthalmic
Tropomyosin receptor kinase B
Retina
03 medical and health sciences
Cellular and Molecular Neuroscience
Nerve Fibers
0302 clinical medicine
Neurotrophic factors
Internal medicine
Prostaglandins, Synthetic
medicine
Humans
Receptor, trkB
Receptor
Antihypertensive Agents
Intraocular Pressure
Aged
Aged, 80 and over
Membrane Glycoproteins
biology
Kinase
Chemistry
Brain-Derived Neurotrophic Factor
Middle Aged
medicine.disease
Immunohistochemistry
Sensory Systems
Ophthalmology
Prostaglandin analog
medicine.anatomical_structure
Endocrinology
nervous system
030221 ophthalmology & optometry
biology.protein
Female
Ophthalmic Solutions
Glaucoma, Open-Angle
030217 neurology & neurosurgery
Neurotrophin
Subjects
Details
- ISSN :
- 14602202 and 02713683
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- Current Eye Research
- Accession number :
- edsair.doi.dedup.....f8678e6ea5c227b65853a74ac0e6e660