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Extensive white matter hyperintensities may increase brain volume in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy

Authors :
Ophélia Godin
Martin Dichgans
Jean Guichard
Dominique Hervé
Ming Yao
Yi-Cheng Zhu
Andreas Gschwendtner
Christian Opherk
Eric Jouvent
Marco Düring
Hugues Chabriat
Source :
Stroke 43(12), 3252-3257 (2012). doi:10.1161/STROKEAHA.112.664854
Publication Year :
2012
Publisher :
Lippincott Williams & Wilkins, 2012.

Abstract

Background and Purpose— The extent of white matter hyperintensities (WMH) is associated with cerebral atrophy in elderly people. WMH is a radiological hallmark of cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), but their relationship with brain volume remains poorly understood. The association between WMH and brain volume was analyzed in a large population of patients with CADASIL. Methods— Demographic and MRI data of 278 patients recruited from a prospective cohort study were analyzed. Volumes of WMH and lacunar infarcts, number of cerebral microbleeds, and brain parenchymal fraction were measured. Multivariate analysis was used to study the impact of WMH on brain volume at baseline. Results— In univariate analyses, brain parenchymal fraction was negatively associated with age, male sex, and all MRI markers. Multiple regression modeling showed that brain parenchymal fraction was inversely related to age, number of cerebral microbleeds, and normalized volume of lacunar infarcts but positively related to normalized volume of WMH ( P P ≤0.001). Conclusion— The results of the present study suggest that extensive WMH may be associated with increase of brain volume in CADASIL. In this disorder, WMH may be related not only to loss of white matter components, but also to a global increase of water content in the cerebral tissue.

Details

Language :
English
Database :
OpenAIRE
Journal :
Stroke 43(12), 3252-3257 (2012). doi:10.1161/STROKEAHA.112.664854
Accession number :
edsair.doi.dedup.....f868046cf8f2a75d641a9ddd3b3f8fdb
Full Text :
https://doi.org/10.1161/STROKEAHA.112.664854