Back to Search
Start Over
New α-Pyridones with Quorum-Sensing Inhibitory Activity from Diversity-Enhanced Extracts of a Streptomyces sp. Derived from Marine Algae
- Source :
- Journal of Agricultural and Food Chemistry. 66:1807-1812
- Publication Year :
- 2018
- Publisher :
- American Chemical Society (ACS), 2018.
-
Abstract
- Four new α-pyrones (1-4) and eight known analogues (5-12) were identified from the secondary metabolites of Streptomyces sp. OUCMDZ-3436 derived from the marine green algae Enteromorpha prolifera. Seven new α-pyridones (14-20) were constructed by diversity-oriented synthesis, which has been an effective approach to expanding the chemical space of natural-product-like compounds. Compounds 16, 17, 19, and 20 were found to have inhibitory effect on the gene expression controlled by quorum sensing in Pseudomonas aeruginosa QSIS-lasI.
- Subjects :
- Pyridones
Chlorophyta
010402 general chemistry
medicine.disease_cause
01 natural sciences
Streptomyces
Algae
Gene expression
medicine
Gene
Molecular Structure
biology
010405 organic chemistry
Chemistry
Pseudomonas aeruginosa
Quorum Sensing
General Chemistry
biology.organism_classification
Anti-Bacterial Agents
0104 chemical sciences
Quorum sensing
Biochemistry
Green algae
General Agricultural and Biological Sciences
Subjects
Details
- ISSN :
- 15205118 and 00218561
- Volume :
- 66
- Database :
- OpenAIRE
- Journal :
- Journal of Agricultural and Food Chemistry
- Accession number :
- edsair.doi.dedup.....f88cceaf60a5637309aa8d165a392f86