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Author Correction: CDER167, a dual inhibitor of URAT1 and GLUT9, is a novel and potent uricosuric candidate for the treatment of hyperuricemia
- Source :
- Acta Pharmacol Sin
- Publication Year :
- 2022
- Publisher :
- Springer Science and Business Media LLC, 2022.
-
Abstract
- Urate transporter 1 (URAT1) and glucose transporter 9 (GLUT9) are important targets for the development of uric acid-lowering drugs. We previously showed that the flexible linkers of URAT1 inhibitors could enhance their potency. In this study we designed and synthesized CDER167, a novel RDEA3710 analogue, by introducing a linker (methylene) between the naphthalene and pyridine rings to increase flexibility, and characterized its pharmacological and pharmacokinetics properties in vitro and in vivo. We showed that CDER167 exerted dual-target inhibitory effects on both URAT1 and GLUT9: CDER167 concentration-dependently inhibited the uptake of [
- Subjects :
- Pharmacology
Dose-Response Relationship, Drug
Molecular Structure
Organic Cation Transport Proteins
Glucose Transport Proteins, Facilitative
Correction
Organic Anion Transporters
Hyperuricemia
General Medicine
Structure-Activity Relationship
HEK293 Cells
Humans
Pharmacology (medical)
RNA, Messenger
Cells, Cultured
Subjects
Details
- ISSN :
- 17457254 and 16714083
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Acta Pharmacologica Sinica
- Accession number :
- edsair.doi.dedup.....f8963820aa6ea01b80dbf9778ee28852