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Cytotoxic, Antiproliferative and Pro-Apoptotic Effects of 5-Hydroxyl-6,7,3′,4′,5′-Pentamethoxyflavone Isolated from Lantana ukambensis
- Source :
- Nutrients, Vol 7, Iss 12, Pp 10388-10397 (2015), NUTRIENTS(7): 12, Nutrients; Volume 7; Issue 12; Pages: 10388-10397, Nutrients, Volume 7, Issue 12, Pages 10388-10397
- Publication Year :
- 2015
- Publisher :
- MDPI AG, 2015.
-
Abstract
- Lantana ukambensis (Vatke) Verdc. is an African food and medicinal plant. Its red fruits are eaten and highly appreciated by the rural population. This plant was extensively used in African folk medicinal traditions to treat chronic wounds but also as anti-leishmanial or cytotoxic remedies, especially in Burkina Faso, Tanzania, Kenya, or Ethiopia. This study investigates the in vitro bioactivity of polymethoxyflavones extracted from a L. ukambensis as anti-proliferative and pro-apoptotic agents. We isolated two known polymethoxyflavones, 5,6,7,3′,4′,5′-hexamethoxyflavone (1) and 5-hydroxy-6,7,3′,4′,5′-pentamethoxyflavone (2) from the whole plant of L. ukambensis. Their chemical structures were determined by spectroscopic analysis and comparison with published data. These molecules were tested for the anti-proliferative, cytotoxic and pro-apoptotic effects on human cancer cells. Among them, 5-hydroxy-6,7,3′,4′,5′-pentamethoxyflavone (2) was selectively cytotoxic against monocytic lymphoma (U937), acute T cell leukemia (Jurkat), and chronic myelogenous leukemia (K562) cell lines, but not against peripheral blood mononuclear cells (PBMCs) from healthy donors, at all tested concentrations. Moreover, this compound exhibited significant anti-proliferative and pro-apoptotic effects against U937 acute myelogenous leukemia cells. This study highlights the anti-proliferative and pro-apoptotic effects of 5-hydroxy-6,7,3′,4′,5′-pentamethoxyflavone (2) and provides a scientific basis of traditional use of L. ukambensis.
- Subjects :
- anti-proliferative
Cell Survival
Lantana
Apoptosis
lcsh:TX341-641
Jurkat cells
Peripheral blood mononuclear cell
Article
Myelogenous
Jurkat Cells
cytotoxic
polymethoxyflavone
Cytotoxic T cell
Medicine
Humans
cancer
Lantana ukambensis
Medicinal plants
Cell Proliferation
Flavonoids
pro-apoptotic
Nutrition and Dietetics
Plants, Medicinal
Traditional medicine
business.industry
Plant Extracts
U937 Cells
medicine.disease
Flavones
Leukemia
Leukocytes, Mononuclear
business
K562 Cells
lcsh:Nutrition. Foods and food supply
Food Science
K562 cells
Chronic myelogenous leukemia
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Volume :
- 7
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....f8ef5e95f9c1728545fa0594ea021e34