Aldol elaboration of 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-ones, masked precursors to acylpyridones

Authors :: Mark E. Light
Abdul K. Choudhury
Raymond C. F. Jones
Terence A. Pillainayagam
Jim Iley
Georgia Loizou
Source :: Beilstein Journal of Organic Chemistry, Vol 8, Iss 1, Pp 308-312 (2012), Beilstein Journal of Organic Chemistry
Publication Year :: 2012
Publisher :: Beilstein-Institut, 2012.
Abstract: A core 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-one scaffold is elaborated at C-3(Me) by base-mediated aldol condensation to give new 3-alkenyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-ones, which are masked forms related to the acylpyridone natural products.

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