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Direct Oral Anticoagulant Therapy for Isolated Distal Deep Vein Thrombosis Associated with Cancer in Routine Clinical Practice
- Source :
- Journal of Clinical Medicine, Journal of Clinical Medicine; Volume 10; Issue 20; Pages: 4648, Journal of Clinical Medicine, Vol 10, Iss 4648, p 4648 (2021)
- Publication Year :
- 2021
-
Abstract
- Background: The efficacy and bleeding complications of direct oral anticoagulant (DOAC) therapy for isolated distal deep vein thrombosis (IDDVT) associated with cancer in routine clinical practice remain unclear. Moreover, prior studies on prolonged therapy for IDDVT are limited. Methods: This retrospective study enrolled 1641 consecutive patients with acute venous thromboembolism (VTE) who had received oral anticoagulant therapy, including warfarin or DOAC, between April 2014 and September 2018 in our institutions. In these patients, 200 patients with cancer-associated IDDVT were evaluated. Results: Mean follow-up period was 780 ± 593 days. Major bleeding and VTE recurrence were observed in 22 (11.0%) and 11 (5.5%) patients, respectively. In multivariate analysis, statistically significant factors correlated with major bleeding were advanced cancer stage, high performance status, stomach cancer, and gallbladder cancer; those correlated with all-cause death were advanced cancer stage, high performance status, liver dysfunction, pancreatic cancer, and major bleeding. Cumulative events of major bleeding and recurrence between patients with prolonged DOAC therapy (≥90 days) and those with nonprolonged therapy were not significantly different. Conclusions: Preventing major bleeding is important because it is a significant risk factor for all-cause death. Major bleeding and recurrent events were comparable between prolonged and nonprolonged therapy.
- Subjects :
- medicine.medical_specialty
Performance status
business.industry
Deep vein
Warfarin
Cancer
Retrospective cohort study
direct oral anticoagulant
General Medicine
medicine.disease
Thrombosis
Gastroenterology
Article
medicine.anatomical_structure
Internal medicine
isolated distal deep vein thrombosis
cancer
medicine
Medicine
Gallbladder cancer
Stomach cancer
business
medicine.drug
Subjects
Details
- ISSN :
- 20770383
- Volume :
- 10
- Issue :
- 20
- Database :
- OpenAIRE
- Journal :
- Journal of clinical medicine
- Accession number :
- edsair.doi.dedup.....f907cca1f141a21c54e648b04ccb3aa6