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Horse Y chromosome assembly displays unique evolutionary features and putative stallion fertility genes
- Source :
- Janečka, J E, Davis, B W, Ghosh, S, Paria, N, Das, P J, Orlando, L, Schubert, M, Nielsen, M K, Stout, T A E, Brashear, W, Li, G, Johnson, C D, Metz, R P, Zadjali, A M A, Love, C C, Varner, D D, Bellott, D W, Murphy, W J, Chowdhary, B P & Raudsepp, T 2018, ' Horse Y chromosome assembly displays unique evolutionary features and putative stallion fertility genes ', Nature Communications, vol. 9, no. 1 . https://doi.org/10.1038/s41467-018-05290-6, Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018), Nature Communications, 9(1). Nature Publishing Group, Nature Communications, Nature communications, vol 9, iss 1
- Publication Year :
- 2018
-
Abstract
- Dynamic evolutionary processes and complex structure make the Y chromosome among the most diverse and least understood regions in mammalian genomes. Here, we present an annotated assembly of the male specific region of the horse Y chromosome (eMSY), representing the first comprehensive Y assembly in odd-toed ungulates. The eMSY comprises single-copy, equine specific multi-copy, PAR transposed, and novel ampliconic sequence classes. The eMSY gene density approaches that of autosomes with the highest number of retained X–Y gametologs recorded in eutherians, in addition to novel Y-born and transposed genes. Horse, donkey and mule testis RNAseq reveals several candidate genes for stallion fertility. A novel testis-expressed XY ampliconic sequence class, ETSTY7, is shared with the parasite Parascaris genome, providing evidence for eukaryotic horizontal transfer and inter-chromosomal mobility. Our study highlights the dynamic nature of the Y and provides a reference sequence for improved understanding of equine male development and fertility.<br />The rapidly evolving Y chromosome accumulates male-benefit genes but is often poorly characterized in many mammals. Here, the authors assemble the male specific region of the horse Y chromosome and investigate its evolution and function.
- Subjects :
- 0301 basic medicine
Male
X Chromosome
Gene Transfer, Horizontal
Evolution
Science
Gene Transfer
Gene Dosage
General Physics and Astronomy
Biology
Y chromosome
Genome
General Biochemistry, Genetics and Molecular Biology
Article
Horizontal
Evolution, Molecular
03 medical and health sciences
Genetic
Molecular evolution
Gene density
Y Chromosome
Testis
Ascaridoidea
Genetics
Animals
Horses
lcsh:Science
Gene
Hybridization
Phylogeny
Comparative genomics
Multidisciplinary
Autosome
Contraception/Reproduction
Human Genome
Molecular
General Chemistry
Equidae
030104 developmental biology
Fertility
Evolutionary biology
Hybridization, Genetic
lcsh:Q
Reference genome
Biotechnology
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Database :
- OpenAIRE
- Journal :
- Janečka, J E, Davis, B W, Ghosh, S, Paria, N, Das, P J, Orlando, L, Schubert, M, Nielsen, M K, Stout, T A E, Brashear, W, Li, G, Johnson, C D, Metz, R P, Zadjali, A M A, Love, C C, Varner, D D, Bellott, D W, Murphy, W J, Chowdhary, B P & Raudsepp, T 2018, ' Horse Y chromosome assembly displays unique evolutionary features and putative stallion fertility genes ', Nature Communications, vol. 9, no. 1 . https://doi.org/10.1038/s41467-018-05290-6, Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018), Nature Communications, 9(1). Nature Publishing Group, Nature Communications, Nature communications, vol 9, iss 1
- Accession number :
- edsair.doi.dedup.....f90b80ef8fe61a049a3473b2f8ef1ae6