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MicroRNA-215 suppresses cell proliferation, migration and invasion of colon cancer by repressing Yin-Yang 1
- Source :
- Biochemical and Biophysical Research Communications. 479:482-488
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Colorectal cancer is one of the most common malignant tumors worldwide with rising incidence. MicroRNAs are small non-coding RNAs that implicate in multiple physiological or pathological processes. The aberrant expression of miRNA-215 (miR-215) has been illustrated in various types of cancers. However, the expression of miR-215 in human colon cancer and the biological roles of it remain largely unknown. We conducted this study to explore the expression and the function of miR-215 in human colon cancer. The results showed that miR-215 was remarkably downregulated in colon cancer tissues and cell lines. Overexpression of miR-215 by miR-215 mimic significantly inhibited colon cancer cell proliferation, migration and invasion while knockdown of miR-215 by miR-215 inhibitor exerted reverse effects. Furthermore, we newly identified Yin-Yang 1(YY1) as a direct target of miR-215 which could rescue the effects of miR-215 on colon cancer cells. In summary, our investigation revealed that miR-215 was downregulated in colon cancer and it suppressed colon cancer cell proliferation, migration and invasion by directly targeting YY1.
- Subjects :
- 0301 basic medicine
Colorectal cancer
Biophysics
Down-Regulation
Apoptosis
Biology
Biochemistry
03 medical and health sciences
0302 clinical medicine
Cell Movement
Cell Line, Tumor
microRNA
medicine
Humans
Neoplasm Invasiveness
Molecular Biology
YY1 Transcription Factor
Cell Proliferation
Gene knockdown
Cell growth
YY1
Cell Biology
HCT116 Cells
medicine.disease
YIN-YANG-1
Gene Expression Regulation, Neoplastic
MicroRNAs
030104 developmental biology
Cell culture
030220 oncology & carcinogenesis
Colonic Neoplasms
Immunology
Cancer research
Function (biology)
Subjects
Details
- ISSN :
- 0006291X
- Volume :
- 479
- Database :
- OpenAIRE
- Journal :
- Biochemical and Biophysical Research Communications
- Accession number :
- edsair.doi.dedup.....f90bb5e9eac95911cb584332036f563e