New Iridoid Derivatives from the Fruits of Cornus officinalis and Their Neuroprotective Activities

Authors :: Xin Wang
Xiang-Jian Zhong
Xiao-Ya Shang
Lin-Lin Ji
Jing Juan
Bo Zhang
Jin-Jie Li
Source :: Molecules, Volume 24, Issue 3, Molecules, Vol 24, Iss 3, p 625 (2019)
Publication Year :: 2019
Publisher :: MDPI, 2019.
Abstract: Three previously undescribed iridoids, cornusfurals A&ndash<br />C, were isolated from the ethanolic extracts of fruits of Cornus officinalis. Their structures were elucidated by spectroscopic methods, including one-dimensional and two-dimensional nuclear magnetic resonance, ultraviolet spectroscopy, infrared spectroscopy, and mass spectrometry. The neuroprotective activity was evaluated by measuring corticosterone-induced damage in PC12 cells. The results showed that cornusfural B decreased corticosterone-induced PC12 cell damage compared with that in model cells.

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