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Specific Laboratory Test for Diagnosis of Multiple Sclerosis
- Source :
- BMJ. 1:412-414
- Publication Year :
- 1974
- Publisher :
- BMJ, 1974.
-
Abstract
- Lymphocytes from patients with multiple sclerosis are much more susceptible to the inhibitory activity of linoleic acid (0.08 mg/ml) when tested for sensitization to thyroid by the macrophage electrophoretic mobility test (91% inhibition) than are those from normal subjects (57% inhibition). Cells from patients with a variety of other neurological diseases give 47% inhibition with linoleic acid. These differences are specific for multiple sclerosis and can be used as an in-vitro diagnostic test for the disease. Nearly 43% of clinically normal near relatives of patients with multiple sclerosis show an "anomalous" figure of about 77%; in the remainder the figure is the same as in the general population (57%). An anomalous result is compatible with lifelong freedom from M.S. Possibly a congenital anomalous handling of unsaturated fatty acids is a constant feature of the disease.
- Subjects :
- Adult
Male
medicine.medical_specialty
Multiple Sclerosis
Linoleic acid
Guinea Pigs
Population
Thyroid Gland
Tuberculin
Disease
In Vitro Techniques
Biology
Gastroenterology
chemistry.chemical_compound
Antigen
Internal medicine
Methods
medicine
Animals
Humans
Lymphocytes
Antigens
education
Sensitization
General Environmental Science
education.field_of_study
Macrophages
Multiple sclerosis
Thyroid
General Engineering
Papers and Originals
General Medicine
Middle Aged
medicine.disease
medicine.anatomical_structure
Linoleic Acids
chemistry
Cell Migration Inhibition
Immunology
General Earth and Planetary Sciences
Female
Subjects
Details
- ISSN :
- 14685833 and 09598138
- Volume :
- 1
- Database :
- OpenAIRE
- Journal :
- BMJ
- Accession number :
- edsair.doi.dedup.....f943874eeb126130ae4b20840f5ec516