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Heavily melanotic perivascular epithelioid clear cell tumor of the kidney
- Source :
- Pathology International. 54:261-265
- Publication Year :
- 2004
- Publisher :
- Wiley, 2004.
-
Abstract
- A black-colored and well-circumscribed renal tumor in a 71-year-old woman is reported. The tumor was unique in that it was rich in vasculature and exclusively composed of perivascular epithelioid clear cells. Morphological features were reminiscent of conventional renal cell carcinoma (RCC). However, immunohistochemical examinations showed that the tumor cells did not express any epithelial markers, but diffusely and intensely expressed a melanocytic marker, gp-100/HMB-45. Another striking feature of the tumor was a large amount of cytoplasmic pigment that made the tumor wholly black. The pigment was not stained with Berlin-blue, completely bleached with potassium permanganate, and stained with Fontana-Masson staining, which suggests that the pigment was melanin. Morphological features and immunohistochemical findings indicated that the present tumor was an extreme example of a perivascular epithelioid clear cell tumor with a large amount of melanin, which has not been previously reported. One should be aware of the pure form of perivascular epithelioid clear cell tumor of the kidney because it is sometimes very difficult to differentiate this tumor from conventional RCC. Immunohistochemical examinations and the presence of cytoplasmic melanin can help the differentiation.
- Subjects :
- Pathology
medicine.medical_specialty
Biology
Pathology and Forensic Medicine
Diagnosis, Differential
Melanin
Antigens, Neoplasm
medicine
Carcinoma
Humans
Carcinoma, Renal Cell
Aged
Inclusion Bodies
Melanins
Kidney
Membrane Glycoproteins
Epithelioid Cells
General Medicine
medicine.disease
Immunohistochemistry
Kidney Neoplasms
Neoplasm Proteins
Staining
HMB-45
medicine.anatomical_structure
Adenocarcinoma
Female
Melanoma-Specific Antigens
Clear cell
Adenocarcinoma, Clear Cell
gp100 Melanoma Antigen
Subjects
Details
- ISSN :
- 14401827 and 13205463
- Volume :
- 54
- Database :
- OpenAIRE
- Journal :
- Pathology International
- Accession number :
- edsair.doi.dedup.....f94a8d6494fe71d5982f2fdb41bde827