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Histology and Biaxial Mechanical Behavior of Abdominal Aortic Aneurysm Tissue Samples
- Source :
- Journal of Biomechanical Engineering. 139
- Publication Year :
- 2017
- Publisher :
- ASME International, 2017.
-
Abstract
- Abdominal aortic aneurysms (AAAs) represent permanent, localized dilations of the abdominal aorta that can be life-threatening if progressing to rupture. Evaluation of risk of rupture depends on understanding the mechanical behavior of patient AAA walls. In this project, a series of patient AAA wall tissue samples have been evaluated through a combined anamnestic, mechanical, and histopathologic approach. Mechanical properties of the samples have been characterized using a novel, strain-controlled, planar biaxial testing protocol emulating the in vivo deformation of the aorta. Histologically, the tissue ultrastructure was highly disrupted. All samples showed pronounced mechanical stiffening with stretch and were notably anisotropic, with greater stiffness in the circumferential than the axial direction. However, there were significant intrapatient variations in wall stiffness and stress. In biaxial tests in which the longitudinal stretch was held constant at 1.1 as the circumferential stretch was extended to 1.1, the maximum average circumferential stress was 330 ± 70 kPa, while the maximum average axial stress was 190 ± 30 kPa. A constitutive model considering the wall as anisotropic with two preferred directions fit the measured data well. No statistically significant differences in tissue mechanical properties were found based on patient gender, age, maximum bulge diameter, height, weight, body mass index, or smoking history. Although a larger patient cohort is merited to confirm these conclusions, the project provides new insight into the relationships between patient natural history, histopathology, and mechanical behavior that may be useful in the development of accurate methods for rupture risk evaluation.
- Subjects :
- Male
medicine.medical_specialty
Finite Element Analysis
0206 medical engineering
Biomedical Engineering
02 engineering and technology
030204 cardiovascular system & hematology
Stress (mechanics)
03 medical and health sciences
0302 clinical medicine
Physiology (medical)
medicine.artery
Materials Testing
medicine
Humans
Aged
Mechanical Phenomena
Aged, 80 and over
Aorta
Deformation (mechanics)
business.industry
Abdominal aorta
Stiffness
Anatomy
Middle Aged
medicine.disease
020601 biomedical engineering
Abdominal aortic aneurysm
Biomechanical Phenomena
Cylinder stress
Female
Histopathology
Stress, Mechanical
medicine.symptom
business
Aortic Aneurysm, Abdominal
Biomedical engineering
Subjects
Details
- ISSN :
- 15288951 and 01480731
- Volume :
- 139
- Database :
- OpenAIRE
- Journal :
- Journal of Biomechanical Engineering
- Accession number :
- edsair.doi.dedup.....f94e6023c1c824a9480c300248144581