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Comparison of Survival Outcomes Between Partial Resection and Biopsy for Primary Glioblastoma: A Propensity Score-Matched Study
- Source :
- World Neurosurgery. 121:e858-e866
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Gross total resection for glioblastoma (GBM) has been associated with better prognosis. However, it is not always feasible, and the threshold for the extent of resection required for better prognosis has been controversial. Therefore, we compared the survival and clinical outcomes of patients with GBM who had undergone partial resection (PR) or biopsy.Of the 110 patients, 32 and 78, who had undergone PR and biopsy, respectively, were enrolled to identify any differences in clinical outcomes. No differences were found in patient demographics between the 2 groups, except for tumor location and mean tumor volume (P = 0.02 and P0.01, respectively). Propensity score matching between the PR and biopsy groups was performed, in which 20 patients each in the PR and biopsy groups were matched.The overall survival (OS) and progression-free survival (PFS) did not differ significantly between the PR and biopsy groups (P = 0.84 and P = 0.48, respectively). After propensity score matching, the differences in OS and PFS between the 2 groups were still not statistically significant (P = 0.51 and P = 0.75, respectively). The hazard ratios for OS and PFS for the PR group compared with biopsy were 0.98 and 0.73, respectively; however, the difference was not statistically significant (P = 0.96 and P = 0.39, respectively). The surgical complication rate was greater in the PR group (14 of 32; 43.7%) than in the biopsy group (9 of 78; 11.5%; P0.01).PR failed to improve survival compared with biopsy for patients with GBM. Moreover, the surgical complication rate in the PR group was greater than that in the biopsy group.
- Subjects :
- Adult
Male
medicine.medical_specialty
Biopsy
Gastroenterology
Neurosurgical Procedures
Young Adult
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
In patient
Propensity Score
DNA Modification Methylases
Aged
Aged, 80 and over
Primary Glioblastoma
medicine.diagnostic_test
Brain Neoplasms
business.industry
Tumor Suppressor Proteins
Hazard ratio
DNA Methylation
Middle Aged
Partial resection
medicine.disease
Magnetic Resonance Imaging
Gross Total Resection
Progression-Free Survival
DNA Repair Enzymes
Treatment Outcome
030220 oncology & carcinogenesis
Propensity score matching
Female
Surgery
Neurology (clinical)
Glioblastoma
business
030217 neurology & neurosurgery
Follow-Up Studies
Subjects
Details
- ISSN :
- 18788750
- Volume :
- 121
- Database :
- OpenAIRE
- Journal :
- World Neurosurgery
- Accession number :
- edsair.doi.dedup.....f95ead50b932cc2f5272ef7838c28918