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A Cysteine‐Mediated Synthesis of Red Phosphorus Nanosheets
- Source :
- Angewandte Chemie International Edition. 60:12524-12531
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Among phosphorus-based nanomaterials, layered black phosphorus and violet phosphorus have been actively explored in the past decade. However, methods for the synthesis of red phosphorus nanosheets (RPNSs) is lacking, even though red phosphorus (RP) is commercially available at low cost and has excellent chemical stability at room temperature. We report an efficient strategy for fabrication of RPNSs and doped RPNSs using cysteine as a reducing reagent. Data from in vitro and in vivo studies suggested that RPNSs can trigger production of reactive oxygen species, DNA damage, and subsequent autophagy-mediated cell death in a shape-dependent manner. Our findings provide a method for construction of layered RP nanomaterials and they present a unique mechanism for the application of phosphorus-based materials in nanomedicines.
- Subjects :
- Boron Compounds
DNA damage
Transplantation, Heterologous
Mice, Nude
chemistry.chemical_element
Apoptosis
010402 general chemistry
01 natural sciences
Catalysis
Cell Line
Nanomaterials
Mice
Neoplasms
Animals
Ferroptosis
Humans
Cysteine
chemistry.chemical_classification
Reactive oxygen species
010405 organic chemistry
Phosphorus
Doping
General Medicine
General Chemistry
Combinatorial chemistry
Nanostructures
0104 chemical sciences
chemistry
A549 Cells
Reducing Agents
Reagent
Chemical stability
Reactive Oxygen Species
DNA Damage
Subjects
Details
- ISSN :
- 15213773 and 14337851
- Volume :
- 60
- Database :
- OpenAIRE
- Journal :
- Angewandte Chemie International Edition
- Accession number :
- edsair.doi.dedup.....f95fb40977b98516b86de1bec6236275