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Relationships of Maternal Body Mass Index and Plasma Biomarkers with Childhood Body Mass Index and Adiposity at 6 years; the Children of SCOPE study
- Source :
- 2019, ' Relationships of maternal body mass index and plasma biomarkers with childhood body mass index and adiposity at 6 years : The Children of SCOPE study ', Pediatric Obesity, vol. 14, no. 10, e12537 . https://doi.org/10.1111/ijpo.12537
- Publication Year :
- 2019
-
Abstract
- BACKGROUND: Maternal obesity has been implicated in the origins of childhood obesity through a suboptimal environment in-utero.OBJECTIVE: We examined relationships of maternal early pregnancy body mass index (BMI), overweight/obesity, and plasma biomarkers of obesity, inflammation, insulin resistance, and placental function with measures of childhood BMI and adiposity.METHODS: BMI z-score, sum of skinfold thicknesses (SST), body fat percentage (BFP, by bioelectrical impedance), and waist, arm, and hip circumferences were measured in 1173 6-year-old children of nulliparous pregnant women in the Screening for Pregnancy Endpoints (SCOPE) study, New Zealand. Relationships of maternal early pregnancy (15 weeks' gestation) BMI and biomarkers with these childhood anthropometric measures were assessed by linear regression, with appropriate adjustment.RESULTS: 28.1% of mothers were classified as overweight and 10.1% with obesity; compared with normal weight mothers, the BFP of their children were 5.3% higher (0.16 SD [95% CI, 0.04-0.29] p = .01) and 7.8% higher (0.27 [0.08-0.47] p = .006) with comparable values for BMI z-score and arm, waist, and hip circumferences. Early pregnancy maternal BMI and plasma placental growth factor (PlGF) were associated with higher child's SST, BMI z-score, hip circumference, and BFP. None of the metabolic or inflammatory maternal biomarkers were associated with childhood obesity.CONCLUSION: In this contemporary large prospective cohort study with extensive maternal/childhood phenotyping and a high prevalence of maternal overweight/obesity, we found independent relationships of maternal early pregnancy BMI with childhood BMI and adiposity; similar associations were observed with PlGF, which may imply a role for placenta function in the developmental programming of childhood obesity risk.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
obesity
Pediatric Obesity
Waist
030209 endocrinology & metabolism
Overweight
Body fat percentage
Childhood obesity
Article
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Pregnancy
medicine
Humans
Mass index
Prospective Studies
Child
Adiposity
030109 nutrition & dietetics
Nutrition and Dietetics
business.industry
Obstetrics
Health Policy
Public Health, Environmental and Occupational Health
nutritional and metabolic diseases
medicine.disease
Obesity
Child obesity
developmental origins of disease
Pediatrics, Perinatology and Child Health
Female
pregnancy
medicine.symptom
business
Body mass index
Biomarkers
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- 2019, ' Relationships of maternal body mass index and plasma biomarkers with childhood body mass index and adiposity at 6 years : The Children of SCOPE study ', Pediatric Obesity, vol. 14, no. 10, e12537 . https://doi.org/10.1111/ijpo.12537
- Accession number :
- edsair.doi.dedup.....f97c8de4dcd6729589f326a89a1419b3