Hypersensitivity of delayed type manifested during the development of allergic lesions of the myocardium

Changes in humoral and cellular responses were studied during the development of allergic lesions of the myocardium in rabbits. These responses, manifestations of hypersensitivity of delayed type, are connected with transformation of cells of the active mesenchyme, responsible for the process of immunogenesis, into lymphocytes and plasma cells. In allergic lesions of the myocardium hypersensitivity of delayed type is manifested as a lympho-marcrophagal reaction in the intermuscular stroma of the heart, the thymus, and the lymph glands and also as blast transformation of the lymphocytes. A complex series of disturbances of immunologic homeostasis arises, in which the primary components are microangiopathies, blast-transformation of lymphocytes and activation of lysosomal enzymes.