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Noncanonical functions of aminoacyl-tRNA synthetases
- Source :
- Biochemistry (Moscow). 77:15-25
- Publication Year :
- 2012
- Publisher :
- Pleiades Publishing Ltd, 2012.
-
Abstract
- Aminoacyl-tRNA synthetases, together with their main function of covalent binding of an amino acid to a corresponding tRNA, also perform many other functions. They take part in regulation of gene transcription, apoptosis, translation, and RNA splicing. Some of them function as cytokines or catalyze different reactions in living cells. Noncanonical functions can be mediated by additional domains of these proteins. On the other hand, some of the noncanonical functions are directly associated with the active center of the aminoacylation reaction. In this review we summarize recent data on the noncanonical functions of aminoacyl-tRNA synthetases and on the mechanisms of their action.
- Subjects :
- DNA Replication
Angiogenesis Inhibitors
Aminoacylation
Biology
Biochemistry
Amino Acyl-tRNA Synthetases
chemistry.chemical_compound
Cytosol
Animals
Humans
Bioorganic chemistry
Cell Nucleus
chemistry.chemical_classification
Aminoacyl tRNA synthetase
Translation (biology)
General Medicine
Mitochondria
Protein Structure, Tertiary
Cell biology
Amino acid
chemistry
Transfer RNA
RNA splicing
Cytokines
RNA
Function (biology)
Subjects
Details
- ISSN :
- 16083040 and 00062979
- Volume :
- 77
- Database :
- OpenAIRE
- Journal :
- Biochemistry (Moscow)
- Accession number :
- edsair.doi.dedup.....f9be346a8ba4bad1097356196cb11466